Phospholipase D, cabbage
Phospholipase D, cabbage is a phospholipase D of the PLD superfamily found in cabbage, acting as a phosphodiesterase and signaling enzyme with activity toward phosphatidylcholine. Phospholipase D hydrolyzes phosphatidylcholine to phosphatidic acid and choline, and catalyzes transphosphatidylation reactions. Phospholipase D can be used for the research of myocardial disease, ischemic heart disease, congestive heart failure, diabetic cardiomyopathy, cardiac hypertrophy, vascular abnormalities, breast cancer, gastric cancer, renal cancer, colorectal cancer.
For research use only. We do not sell to patients.
- CAS No.: 9001-87-0
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Cabbage phospholipase D exhibits substrate specificity, and it does not hydrolyze rac. 1,2-diacylglycerol-3-phosphocholine with a 2-alkyl substitution at the sn-2 position[1].
Phospholipase D, cabbage is soluble at pH 5.6.
Phospholipase D hydrolyzes choline phospholipids to quantify the incorporation of propargylcholine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 9001-87-0
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SMILES
[Phospholipase D, cabbage]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shukla SD, Halenda SP. Phospholipase D in cell signalling and its relationship to phospholipase C. Life sciences. 1991;48(9):851-66. [Content Brief]
[2]. Selvy PE, et al. Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev. 2011 Oct 12;111(10):6064-119. [Content Brief]
[3]. Jao CY, Roth M, Welti R, et al.. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2009 Sep 08;106(36):15332-7. [Content Brief]
[4]. Tappia PS, et al. Oxidative stress and redox regulation of phospholipase D in myocardial disease. Free Radic Biol Med. 2006 Aug 1;41(3):349-61. [Content Brief]
[5]. Foster DA, Xu L. Phospholipase D in cell proliferation and cancer. Mol Cancer Res. 2003 Sep;1(11):789-800. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phospholipase D, cabbage Related Classifications
HY-P2812B Related Classifications
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