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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2438 Results for "
decrease
" in MedChemExpress (MCE) Product Catalog:
Products (2438)
2438 Results for "decrease" in MCE Product Catalog:
Cat. No.: HY-165624
CAS No.: 140221-50-7
Target:
Research Areas:
LY-41 is a 2-aminotetralin (HY-W022362) derivative related to 8-OH-DPAT (HY-112061). LY-41 decreases 5-HT synthesis. LY-41 induces 5-HT motor syndrome. (R)-LY-41 and (S)-LY-41 are novel 5-HT1A receptor agonists .
Cat. No.: HY-171148
CAS No.: 3019907-96-8
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F1-RIBOTAC is a ribonuclease-targeting chimeras (RIBOTACs). F1-RIBOTAC decreases QSOX1-a mRNA expression level in an RNase L-dependent manner. F1-RIBOTAC can be used for the research of cancer . (Pink: RNA ligand (HY-168452); Black: linker (HY-W008005); Blue: RNase L ligand (HY-156839))
Cat. No.: HY-178196
SDH-IN-32 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 2.74 μM. SDH-IN-32 exhibits excellent antifungal activity. SDH-IN-32 can destroy the cell membrane structure and increase the permeability of the cell membrane. SDH-IN-32 can decrease the mitochondrial membrane potential (MMP), thereby inducing cell apoptosis and inhibiting the normal growth of mycelia. SDH-IN-32 can be used for the research of infection .
Cat. No.: HY-178928
Target:
Research Areas:
KV1.3-IN-3 (Compound 13a) is a KV1.3 channel inhibitor. KV1.3-IN-3 decreases the Kv1.3 peak current amplitude by more than 80%. KV1.3-IN-3 exhibits excellent pharmacological properties and safety. KV1.3-IN-3 can be used for the study of autoimmunity disease .
Cat. No.: HY-180220
Target:
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GLP-1R agonist 40 (Compound I-1) is an orally active, potent and selective GLP-1R agonist (EC50 = 26.7 pM for cAMP accumulation). GLP-1R agonist 40 shows significant decrease in blood glucose levels. GLP-1R agonist 40 can be used in the research of type 2 diabetes .
Cat. No.: HY-182392
CAS No.: 925644-66-2
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NFYi5 is a nuclear transcription factor-Y (NF-Y) inhibitor. NFYi5 disrupts the binding of NF-Y to DNA, accelerates the ubiquitin-independent degradation of the NF-YA subunit, and reduces the transcriptional activity of NF-Y. As an antimitotic agent, NFYi5 decreases the mRNA levels of NF-Y target genes without affecting the expression of housekeeping genes, and inhibits cell proliferation. NFYi5 can be used in the research of tissue fibrosis .
Cat. No.: HY-182414
CAS No.: 81907-78-0
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NCO-650 free base is an antiallergic agent that acts by inhibiting tryptase, a key trypsin-like protease in mast cells. NCO-650 free base inhibits mast cell histamine release, increases intracellular cAMP levels in mast cells, suppresses bronchoconstriction, and prevents decreases in perfusion pressure and systemic blood pressure. NCO-650 free base is applicable to the research of allergic diseases and bronchial asthma .
Cat. No.: HY-182448
CAS No.: 3056015-44-9
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TDI-11904 is a peripherally active EZH2 inhibitor with an EZH2 IC50 of 0.9 nM. TDI-11904 inhibits EZH2 methyltransferase activity, reduces the trimethylation level of H3K27me3, and decreases intracellular H3K27me3 content. TDI-11904 inhibits the proliferation of lymphoma cells. TDI-11904 can be used for the research of lymphoma .
Cat. No.: HY-187115
CAS No.: 20762-32-7
Research Areas:
GGW is a tripeptide with neuroprotective activity. GGW blocks the mitochondria-mediated apoptosis pathway, reverses glutamate-induced upregulation of the pro-apoptotic protein Bax and downregulation of the anti-apoptotic protein Bcl-2. GGW reduces ROS production, reverses the depletion of SOD and Glutathione Peroxidase, decreases intracellular calcium concentration, and reverses the collapse of mitochondrial membrane potential. GGW can be used in studies related to memory impairment induced by sleep deprivation .
Cat. No.: HY-187164
CAS No.: 78945-99-0
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HCV NS5B polymerase-IN-5 is a HCV NS5B polymerase inhibitor with an IC50 value of 47.9 μM. HCV NS5B polymerase-IN-5 reduces the production of inorganic pyrophosphate and decreases the nucleoside triphosphate incorporation of HCV NS5B polymerase. HCV NS5B polymerase-IN-5 can be used in studies related to hepatitis C virus infection .
Cat. No.: HY-190728
Research Areas:
SDH-IN-56 is a succinate dehydrogenase (SDH) inhibitor that blocks succinate oxidation and fungal energy metabolism. SDH-IN-56 disrupts fungal cell membrane integrity and increases membrane permeability, leading to leakage of intracellular contents and a decrease in extracellular pH. SDH-IN-56 induces intracellular reactive oxygen species (ROS) accumulation and loss of mitochondrial membrane potential. SDH-IN-56 can be used for research on fungal infections .
Cat. No.: HY-B0093AS
CAS No.: 1279026-26-4
Synonyms: CGS14824A-d5 hydrochloride
Cat. No.: HY-B0094S3
Synonyms: Qinghaosu-13C,d4; NSC 369397-13C,d4
Cat. No.: HY-B1899S
CAS No.: 2044276-15-3
Synonyms: Taurodeoxycholate-d5
Research Areas:
Taurodeoxycholic acid-d5 is the deuterium labeled Taurodeoxycholic acid (HY-B1899) . Taurodeoxycholic acid, a bile acid, stabilizes the mitochondrial membrane, decreases free radical formation. Taurodeoxycholic acid inhibits apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxycholic acid exhibits neuroprotective effect in 3-nitropropionic acid induced mouse model or genetic mouse model of Huntington's disease (HD) .
Cat. No.: HY-D3382
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SGC3 is a fluorescent dye with lipophilic properties. SGC3 can be used to study synaptic vesicle recycling and "kiss-and-run" exocytosis by monitoring dye efflux through nanoscale fusion pores, and its detection mechanism relies on its own lipophilic properties. SGC3 generates fluorescence when bound to lipid membranes, and a decrease in fluorescence intensity can be detected when SGC3 leaves vesicles and exists in a free state in solution .
Cat. No.: HY-N0702
CAS No.: 20183-47-5
Target:
Cat. No.: HY-N11729
CAS No.: 1415504-32-3
Category:
Target:
Cat. No.: HY-N16557
CAS No.: 77398-92-6
Category:
Cat. No.: HY-N2410R
CAS No.: 66648-43-9
Synonyms: N-feruloyltyramine (Standard); Moupinamide (Standard)
Cat. No.: HY-N8529
CAS No.: 73340-44-0
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
