Sirtratumab
Based on 1 Customer Validation
Sirtratumab (AGS15C; Ha15-10ac12; Ha15-10ac12.1) is a SLITRK6-specific humanized IgG2 monoclonal antibody, and serves as the parental antibody of the ADC ASG-15ME (HY-P99595). Sirtratumab is applicable for cancer research.
For research use only. We do not sell to patients.
- Purity : ≥99.0%
- CAS No.: 1824663-82-2
- Molecular Weight:146 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG2 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
SLITRK6
In Vitro
Sirtratumab (0.00067-40 nmol/L; overnight at 4°C) binds with high affinity to SLITRK6 expressed on SW-780 bladder transitional cell carcinoma cells, with a Kd of 0.015 nmol/L[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG2 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow Cytometry analysis of SK-N-SH cells labelling SLITRK6 (red) with Sirtratumab (anti-SLITRK6) (HY-P99964). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG2 kappa (HY-P99002). Black-Unlabelled control, cells without incubation with primary antibody. -
Immobilized HY-P77208 SLITRK6 Protein, Human (HEK293, His) can bind Sirtratumab. The EC50 for this effect is 19.86 ng/mL.
Chemical Information
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CAS No. 1824663-82-2
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Appearance Liquid
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Molecular Weight 146 kDa
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Color Colorless to light yellow
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SMILES
[Sirtratumab]
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Synonyms
AGS15C; Ha15-10ac12; Ha15-10ac12.1
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)