Tafamidis-d3
Based on 1 Customer Validation
Tafamidis-d3 (Fx-1006A-d3 (free acid)) is the deuterated-labeled Tafamidis (HY-14852). Tafamidis (Fx-1006A (free acid)) is an orally active and selective transthyretin (TTR) stabilizer. Tafamidis binds to the thyroxine binding site with negative cooperativity, stabilizes the TTR tetramer, slows TTR tetramer dissociation and subunit exchange, and inhibits TTR fibril formation. Tafamidis can be used in research on nervous system-related diseases.
For research use only. We do not sell to patients.
- Purity : 99.39%
- Formula: C14H4D3Cl2NO3
- Molecular Weight:311.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
EC50: 2.7-3.2 μM (TTR)[1]
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 594839-88-0
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Appearance Solid
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Molecular Weight 311.13
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Formula C14H4D3Cl2NO3
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Color White to off-white
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SMILES
O=C(C1=C([2H])C([2H])=C2N=C(C3=CC(Cl)=CC(Cl)=C3)OC2=C1[2H])O
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Synonyms
Fx-1006A-d3 free acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 37.5 mg/mL (120.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (285 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.2141 mL | 16.0705 mL | 32.1409 mL | 80.3523 mL |
| 5 mM | 0.6428 mL | 3.2141 mL | 6.4282 mL | 16.0705 mL | |
| 10 mM | 0.3214 mL | 1.6070 mL | 3.2141 mL | 8.0352 mL | |
| 15 mM | 0.2143 mL | 1.0714 mL | 2.1427 mL | 5.3568 mL | |
| 20 mM | 0.1607 mL | 0.8035 mL | 1.6070 mL | 4.0176 mL | |
| 25 mM | 0.1286 mL | 0.6428 mL | 1.2856 mL | 3.2141 mL | |
| 30 mM | 0.1071 mL | 0.5357 mL | 1.0714 mL | 2.6784 mL | |
| 40 mM | 0.0804 mL | 0.4018 mL | 0.8035 mL | 2.0088 mL | |
| 50 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6070 mL | |
| 60 mM | 0.0536 mL | 0.2678 mL | 0.5357 mL | 1.3392 mL | |
| 80 mM | 0.0402 mL | 0.2009 mL | 0.4018 mL | 1.0044 mL | |
| 100 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8035 mL |
Tafamidis-d3 Related Classifications
HY-14852S Related Classifications
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