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Cat. No.: HY-W702106

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2-Methyl estradiol

2-Methyl estradiol, an endogenous metabolite of Estradiol (HY-B0141), inhibits cell proliferation and angiogenesis, with IC₅₀ values of 3 and 2.39 μM for HUVEC and MCF-7 human breast cancer cell proliferation, respectively.

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CAS No.: 1818-12-8
Formule: C₁₉H₂₆O₂
Masse moléculaire:286.41

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

2-Methyl estradiol Chemical Structure

CAS No.: 1818-12-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	GI₅₀	16 μM Compound: 9	Cytotoxicity against prostate DU-145 cancer cell lines. Cytotoxicity against prostate DU-145 cancer cell lines.	[PMID: 7783135]
DU-145	GI₅₀	51 μM Compound: 8	Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay Antiproliferative activity against human DU145 cells after 96 hrs by WST1 assay	[PMID: 17696419]
HCT-116	GI₅₀	3.6 μM Compound: 9	Cytotoxicity against colon HCT116 cancer cell lines. Cytotoxicity against colon HCT116 cancer cell lines.	[PMID: 7783135]
HOP-62	GI₅₀	11 μM Compound: 9	Cytotoxicity against lung HOP-62 cancer cell lines. Cytotoxicity against lung HOP-62 cancer cell lines.	[PMID: 7783135]
MDA-MB-435	GI₅₀	1.8 μM Compound: 9	Cytotoxicity against breast MDA-MB-435 cancer cell lines. Cytotoxicity against breast MDA-MB-435 cancer cell lines.	[PMID: 7783135]
OVCAR-3	GI₅₀	9.1 μM Compound: 9	Cytotoxicity against ovarian OVCAR-3 cancer cell lines. Cytotoxicity against ovarian OVCAR-3 cancer cell lines.	[PMID: 7783135]
Panel (Carcinoma cell lines)	GI₅₀	8.1 μM Compound: 9	Mean graph midpoint for all human cancer cell line cytotoxicity. Mean graph midpoint for all human cancer cell line cytotoxicity.	[PMID: 7783135]
SF-539	GI₅₀	7.4 μM Compound: 9	Cytotoxicity against CNS SF-539 cancer cell lines. Cytotoxicity against CNS SF-539 cancer cell lines.	[PMID: 7783135]
SN12C	GI₅₀	17 μM Compound: 9	Cytotoxicity against renal SN12C cancer cell lines. Cytotoxicity against renal SN12C cancer cell lines.	[PMID: 7783135]
UACC-62	GI₅₀	5.4 μM Compound: 9	Cytotoxicity against melanoma UACC-62 cancer cell lines. Cytotoxicity against melanoma UACC-62 cancer cell lines.	[PMID: 7783135]

Chemical Information

CAS No. 1818-12-8
Masse moléculaire 286.41
Formule C₁₉H₂₆O₂
SMILES

C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(C)=C(O)C=C4CC3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Iljung Lee, et al. 2-[methyl-(11)C]methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis. Nucl Med Biol. 2007 Aug;34(6):625-31. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

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100 mg

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