2-Thio-UTP
2-Thio-UTP is a selective P2Y2 inhibitor with an EC50 value of 50 nM. 2-Thio-UTP reduces pro-fibrotic gene expression and protein α-smooth muscle actin. 2-Thio-UTP has the potential for the research of calcific aortic valve stenosis (CAVS) .
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- CAS No.: 35763-29-2
- Formule: C9H15N2O14P3S
- Masse moléculaire:500.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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P2Y2 Receptor 50 nM (EC50) |
2-Thio-UTP (10 µM; 5 days) reduces the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1 and reduces the protein of αSMA in valve interstitial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:valve interstitial cells
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Concentration:10 µM
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Incubation Time:5 days
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Result:Reduced the αSMA protein expression.
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Cell Line:valve interstitial cells
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Concentration:10 µM
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Incubation Time:5 days
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Result:Significantly reduced the mRNA expression of ACTA2, TGFB1, TGFB2, COL1A1, COL3A1.
Chemical Information
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CAS No. 35763-29-2
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Masse moléculaire 500.21
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Formule C9H15N2O14P3S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=S)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. El-Tayeb A, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [Content Brief]
[2]. Moschetta D, et al. Purinergic Receptor P2Y2 Stimulation Averts Aortic Valve Interstitial Cell Calcification and Myofibroblastic Activation. Biomedicines. 2022 Feb 16;10(2):457. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Thio-UTP Related Classifications
HY-116307 Related Classifications
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