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Cat. No.: HY-113322

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3-Hydroxyquinine

Name: 3-Hydroxyquinine
Brand: MedChemExpress
SKU: HY-113322
Price: 509.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: 3-Hydroxyquinidine)

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3-Hydroxyquinine (3-Hydroxyquinidine) is the major metabolite of Quinine (HY-D0143) and a biomarker of CYP3A4 activity. 3-Hydroxyquinine is formed through CYP3A4-mediated 3-hydroxylation catalyzed by CYP3A isoforms.

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Pureté : 98.13%
CAS No.: 53467-23-5
Formule: C₂₀H₂₄N₂O₃
Masse moléculaire:340.42

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

3-Hydroxyquinine Chemical Structure

CAS No.: 53467-23-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Cytochrome P450 :

In Vitro

3-Hydroxyquinine (100-500 μM quinine; 30 min) is the major metabolite generated from quinine by human liver microsomes^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 53467-23-5
Appearance Solid
Masse moléculaire 340.42
Formule C₂₀H₂₄N₂O₃
Color White to off-white
SMILES

C=C[C@](C[N@@]1CC2)(O)[C@@H]2C[C@@H]1[C@@H](O)C3=CC=NC4=CC=C(OC)C=C34
Synonyms

3-Hydroxyquinidine
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhou XY, et al. Enzymatic activities of CYP3A4 allelic variants on quinine 3-hydroxylation in vitro. Frontiers in pharmacology. 2019 May 31;10:591.

[2]. Marcsisin SR, et al. CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever. Malaria journal. 2013 Jun 21;12:214.

[3]. Zhang H, et al. Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine. British journal of clinical pharmacology. 1997 Mar;43(3):245-52.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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