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Cat. No.: HY-112444

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BACE1-IN-2

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM.

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CAS No.: 1352416-78-4
Formule: C₁₉H₁₅F₄N₅O₂
Masse moléculaire:421.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BACE1-IN-2 Chemical Structure

CAS No.: 1352416-78-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

BACE1-IN-2 is a 1,4-Oxazine β-Secretase 1 (BACE1) inhibitor with an IC₅₀ of 22 nM^[1].

IC₅₀ & Target

BACE1

Voir tous les produits spécifiques à Isoform Beta-secretase :

BACE1
BACE2

In Vitro

BACE1-IN-2 (Compound 3) is 10-fold more potent toward BACE1 than BACE2, inhibition of which may lead to hair depigmentation. BACE1-IN-2 inhibits hAβ42 cell with an IC₅₀ of 6.0 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1352416-78-4
Masse moléculaire 421.35
Formule C₁₉H₁₅F₄N₅O₂
SMILES

NC1=N[C@@](C2=C(F)C=CC(NC(C3=CC=C(C#N)C=N3)=O)=C2)(C)[C@H](C(F)(F)F)OC1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gijsen HJM, et al. Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. J Med Chem. 2018 Jun 28;61(12):5292-5303. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Quantité:
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BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Voir tous les produits spécifiques à Isoform Beta-secretase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Bioz

BACE1-IN-2

Verubecestat

LY2886721

Lanabecestat

LY2811376

AZD3839 free base

Elenbecestat

BACE1-IN-1

Verubecestat (Standard)

LY2811376 (Standard)

Elenbecestat (Standard)

BACE1-IN-1 (Standard)

Lanabecestat (Standard)

Voir tous les produits spécifiques à Isoform Beta-secretase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BACE1-IN-2 Related Classifications

HY-112444 Related Classifications

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