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Diosmin

21 Cited Publications
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Based on 21 publication(s) in Google Scholar

Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

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  • Pureté: 98.62%
  • CAS No.: 520-27-4
  • Formule: C28H32O15
  • Masse moléculaire:608.54
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Diosmin Chemical Structure
    Diosmin Chemical Structure
  • Experimental Validation Results for Diosmin
  • Experimental Validation Results for Diosmin
  • Experimental Validation Results for Diosmin
  • Experimental Validation Results for Diosmin
  • Experimental Validation Results for Diosmin
  • Experimental Validation Results for Diosmin
CAS No.: 520-27-4
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  • Diosmin Chemical Structure
    Diosmin Chemical Structure
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  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     N2a cells were treated with DMSO, Diosmin (Dio; 40 μM), FICZ (250 nM), Indole-3-acetamide (I3C; 10 μM) or L-KN (3 μM) for 12 h. Whole cell extracts were examined by western blotting with the indicated antibodies. NEP expression was adjusted to that of β-actin, which was used as the loading control. n = 3.

  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     N2a-APP cells were treated with Diosmin (Dio; 80 μM), FICZ (250 nM), L-KN (3 μM) or Indole-3-acetamide (I3C; 10 μM) with or without SR1 (2 μM) or Sacubitril (Sac; 1 μM) for 24 h, the supernatant was collected and the Aβ42 levels were determined by ELISA.

  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     N2a cells were treated with DMSO or Diosmin (Dio; 40 µM) for 6 h, the total mRNA was extracted and the mRNA levels of Cyp1a1, Cyp1b1 and Gst were determined by qRT-PCR.

  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     Diosmin (Dio; 0, 20, 40, 80 μM; 12 h/ 80 μM; 0, 6, 24 h) promoted NEP expression in a dose and time-dependent manner.

  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     Diosmin (Dio; 10, 20, 40 mg/kg; PO; daily for 4 weeks) showed the NEP protein levels in the cortex and hippocampus of the APP/PS1 mice were increased by the diosmin treatment compared with the vehicle control.

  • 1/16

    Diosmin purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Aug 11;11(18):8797-8812. [Abstract]

    Customer Validation
     Diosmin (Dio; PO; daily for 4 weeks) significantly elevated in the neuron cell bodies in the cortex (Figure A), cornus ammonis 3 (CA3) (Figure B), CA1 (Figure C), and dentate gyrus (DG) (Figure D).

  • Diosmin