GNE-955
GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.
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- CAS No.: 1527523-39-2
- Formule: C22H24N8O
- Masse moléculaire:416.48
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PIM1 0.018 nM (Ki) |
PIM2 0.11 nM (Ki) |
PIM3 0.08 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
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| MM1.S | IC50 |
0.5 μM
Compound: 20
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Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MM1S cells after 72 hrs by CellTiter-Glo assay
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[PMID: 28445037] |
GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment[1].
GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1527523-39-2
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Masse moléculaire 416.48
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Formule C22H24N8O
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SMILES
CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[C@H](N)C5)=N4)C=N2)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GNE-955 Related Classifications
HY-101783 Related Classifications
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