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GSK484 hydrochloride

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Based on 54 publication(s) in Google Scholar

GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.

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  • Pureté: 99.48%
  • CAS No.: 1652591-81-5
  • Formule: C27H32ClN5O3
  • Masse moléculaire:510.03
  • Stockage:

    4°C, stored under nitrogen, away from moisture

    * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen, away from moisture)

  • GSK484 hydrochloride Chemical Structure
    GSK484 hydrochloride Chemical Structure
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
  • Experimental Validation Results for GSK484 hydrochloride
CAS No.: 1652591-81-5
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Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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  • GSK484 hydrochloride Chemical Structure
    GSK484 hydrochloride Chemical Structure
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  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2025 Sep 8;43(9):1758-1775.e8. [Abstract]

    Customer Validation
     Schema for GSK484 treatment protocol and summary tumor growth curves of MC38 in Dnase1l3fl/fl and Dnase1l3cko mice (n = 7).

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are BLI quantification of primary tumor growth at day 19.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are BLI quantification of lung metastasis at week 5.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are pulmonary surface nodules at week 5.

  • 1/16

    GSK484 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2021 Mar 8;39(3):423-437.e7. [Abstract]

    Customer Validation
     Mice were treated with GSK484 (20 mg/kg, i.p. daily shots for 20 days from day 7, and then maintenance shots every two days) following orthotopic injection of AT3 cells. Shown are NET formation in lung metastases.

  • GSK484 hydrochloride