Metaldehyde
Based on 1 Customer Validation
Metaldehyde is an orally active molluscicide. Metaldehyde acts as a feeding inhibitor. Metaldehyde disrupts the feeding cycle, impairs righting ability, delays fecal excretion, induces toxic symptoms in slugs, reduces the concentrations of neurotransmitters (Noradrenaline, 5-HT (HY-B1473A)) in the mouse brain, and induces lethal clonic-tonic convulsions in mice.
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- Pureté: 98.0%
- CAS No.: 108-62-3
- Formule: C8H16O4
- Masse moléculaire:176.21
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Metaldehyde (1 g/L) does not alter any measured hemocyte parameters in in vitro cultures of Crassostrea gigas hemocytes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Metaldehyde (p.o.) exhibits moderate acute oral toxicity in rabbits, with an LD50 ranging from 290 to 1250 mg/kg[1].
Metaldehyde (p.o.) exhibits moderate acute oral toxicity in mice, with an LD50 of 200 mg/kg[1].
Metaldehyde (p.o.) exhibits moderate acute oral toxicity in guinea pigs, with an LD50 range of 175-700 mg/kg[1].
Metaldehyde (p.o.) exhibits moderate acute oral toxicity in dogs, with an LD50 range of 100-1000 mg/kg, and lethal effects occur at doses of 250-1000 mg/kg[1].
Metaldehyde (following water exposure) exhibits acute aquatic toxicity to rainbow trout and bluegill sunfish, with an LD50 of ≤100 µg/L[1].
Metaldehyde (30 mg; 1 g/kg; p.o.; single administration) induces fatal clonic-tonic convulsions in mice within 2 hours and significantly reduces the concentrations of NA, 5-HT and 5-HIAA in mouse brains; the 30 mg dose reduces the levels of these amines to 12%, 17% and 17% of those in the control group, respectively[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:unspecified strain; unspecified strain[1]
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Dosage:Not specified
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Administration:water exposure
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Result:Recorded LD50 values of not more than 100 µg/L for both species.
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Animal Model:Albino mice (both sexes, adult, 30-35 g, laboratory-bred)[4]
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Dosage:1 g/kg; 30 mg
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Administration:p.o.; single dose
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Result:Killed all mice within 2 hours.
Reduced brain noradrenaline (NA), 5-hydroxytryptamine (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) concentrations significantly relative to control values.
Reduced brain NA, 5-HT, and 5-HIAA concentrations to 12%, 17%, and 17% of control values, respectively (all significantly lower than control values at P < 0.001).
Chemical Information
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CAS No. 108-62-3
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Appearance Solid
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Masse moléculaire 176.21
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Formule C8H16O4
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Color White to off-white
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SMILES
CC1OC(C)OC(C)OC(C)O1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 1.82 mg/mL (10.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[3]. Moreau P, et al. In vivo effects of metaldehyde on Pacific oyster, Crassostrea gigas: comparing hemocyte parameters in two oyster families. Environmental science and pollution research international. 2015 Jun;22(11):8003-9. [Content Brief]
[4]. Homeida AM, et al. Pharmacological aspects of metaldehyde poisoning in mice. Journal of veterinary pharmacology and therapeutics. 1982 Mar;5(1):77-81. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6750 mL | 28.3752 mL | 56.7505 mL | 141.8762 mL |
| 5 mM | 1.1350 mL | 5.6750 mL | 11.3501 mL | 28.3752 mL | |
| 10 mM | 0.5675 mL | 2.8375 mL | 5.6750 mL | 14.1876 mL |
Metaldehyde Related Classifications
HY-B1870 Related Classifications
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