Napsagatran
Napsagatran (Ro 46-6240) is a potent thrombin inhibitor. Napsagatran exhibits anticoagulant effects in vitro and in vivo. Napsagatran can be used in antithrombotic research[1][2].
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- CAS No.: 154397-77-0
- Formule: C26H34N6O6S
- Masse moléculaire:558.65
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Napsagatran (10 μg/kg/min) reduces platelet-rich thrombus formation in an ex vivo perfusion chamber model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Napsagatran (10 μg/kg/min, i.v., infusion for 240 minutes) significantly reduces thrombus associated fibrin in rabbits[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:New Zealand rabbits[2]
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Dosage:10 μg/kg/min
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Administration:i.v., infusion for 240 minutes
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Result:Showed a 1.3-fold prolongation of the prothrombin time (PT) and a 1.7-fold prolongation of the partial thromboplastin time (APTT).
Significantly reduced thrombus associated fibrin after 240 min blood flow exposure.
Showed no effects in heart rate, blood pressure, plasma fibrinogen concentrations, hematocrit and blood cell counts over time.
Chemical Information
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CAS No. 154397-77-0
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Masse moléculaire 558.65
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Formule C26H34N6O6S
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SMILES
O=C(NC[C@H]1CN(C(N)=N)CCC1)C[C@@H](C(N(C2CC2)CC(O)=O)=O)NS(C3=CC4=CC=CC=C4C=C3)(=O)=O
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Synonyms
Ro 46-6240; Ro 46-6240/010
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Roux S, et al. Effects of napsagatran (Ro 46-6240), a new synthetic thrombin inhibitor and of heparin in a canine model of coronary artery thrombosis: comparison with an ex vivo annular perfusion chamber model. J Pharmacol Exp Ther. 1996 Apr;277(1):71-8. [Content Brief]
[2]. Himber J, et al. Inhibition of tissue factor limits the growth of venous thrombus in the rabbit. J Thromb Haemost. 2003 May;1(5):889-95. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Napsagatran Related Classifications
HY-15759 Related Classifications
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