Tavilermide
Based on 2 publication(s) in Google Scholar
Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
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- Pureté: 99.57%
- CAS No.: 263251-78-1
- Formule: C24H32N6O11
- Masse moléculaire:580.54
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Tavilermide
More
Activité biologique
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TrkA |
Tavilermide (MIM-D3) is a tyrosine kinase TrkA receptor agonist, which can be used to treat dry eye.Tavilermide is a proteolytically stable, cyclic peptidomimetic that has been shown to be a partial TrkA receptor agonist. Tavilermide demonstrates activities similar to NGF (but does not bind to the p75NTR receptor) and can potentiate the effects of suboptimal concentrations of NGF[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 263251-78-1
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Appearance Solid
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Masse moléculaire 580.54
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Formule C24H32N6O11
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Color White to off-white
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SMILES
O=C(O)CC[C@H](N1)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(O)=O)=O)CCOC2=CC=C([N+]([O-])=O)C=C2C1=O)=O)=O
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Synonyms
MIM-D3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Brain
Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies. [Abstract]2022 Aug 27;145(8):2806-2822. PMID: 34919633 -
Nanoscale
Synergistically dual-functional nano eye-drops for simultaneous anti-inflammatory and anti-oxidative treatment of dry eye disease. [Abstract]2019 Mar 21;11(12):5580-5594. PMID: 30860532
Solvant et solubilité
NH4OH : 50 mg/mL (86.13 mM; ultrasonic and adjust pH to 10 with NH4OH)
H2O : 2 mg/mL (3.45 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 4.17 mg/mL (7.18 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 25 mg/mL (43.06 mM); Suspended solution; Need ultrasonic
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 10 mg/mL (17.23 mM); Suspended solution; Need ultrasonic
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / NH4OH | 1 mM | 1.7225 mL | 8.6127 mL | 17.2253 mL | 43.0634 mL |
| NH4OH | 5 mM | 0.3445 mL | 1.7225 mL | 3.4451 mL | 8.6127 mL |
| 10 mM | 0.1723 mL | 0.8613 mL | 1.7225 mL | 4.3063 mL | |
| 15 mM | 0.1148 mL | 0.5742 mL | 1.1484 mL | 2.8709 mL | |
| 20 mM | 0.0861 mL | 0.4306 mL | 0.8613 mL | 2.1532 mL | |
| 25 mM | 0.0689 mL | 0.3445 mL | 0.6890 mL | 1.7225 mL | |
| 30 mM | 0.0574 mL | 0.2871 mL | 0.5742 mL | 1.4354 mL | |
| 40 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0766 mL | |
| 50 mM | 0.0345 mL | 0.1723 mL | 0.3445 mL | 0.8613 mL | |
| 60 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL | |
| 80 mM | 0.0215 mL | 0.1077 mL | 0.2153 mL | 0.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tavilermide Related Classifications
HY-17622 Related Classifications
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