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Cat. No.: HY-U00316

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Vinconate

Name: Vinconate
Brand: MedChemExpress
SKU: HY-U00316
Availability: PreOrder

(Synonyms: Chanodesethylapovincamine)

Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

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CAS No.: 70704-03-9
Formule: C₁₈H₂₀N₂O₂
Masse moléculaire:296.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Vinconate Chemical Structure

CAS No.: 70704-03-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

IC₅₀ & Target

muscariic acetylcholine receptor^[1]

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In Vivo

Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate^[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [³H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [³H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [³H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [³H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 70704-03-9
Masse moléculaire 296.36
Formule C₁₈H₂₀N₂O₂
SMILES

O=C(C1=CCC2N(CC)CCC3=C2N1C4=C3C=CC=C4)OC
Synonyms

Chanodesethylapovincamine
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Iino T, et al. Effect of vinconate, an indolonaphthyridine derivative, on dopamine and serotonin concentrations in dialysate from the striatum of freely moving rats: brain microdialysis studies. J Pharmacol Exp Ther. 1996 Aug;278(2):614-9. [Content Brief]

[2]. Araki T, et al. Effects of vinconate on neurotransmitter receptor systems in aged rat brain. Environ Toxicol Pharmacol. 1996 Dec 20;2(4):343-9. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Vinconate

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