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Vps34-IN-1

17 Cited Publications
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Based on 17 publication(s) in Google Scholar

Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC50 of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy.

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  • Pureté: 99.79%
  • CAS No.: 1383716-33-3
  • Formule: C21H24ClN7O
  • Masse moléculaire:425.91
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Vps34-IN-1 Chemical Structure
    Vps34-IN-1 Chemical Structure
  • Experimental Validation Results for Vps34-IN-1
  • Experimental Validation Results for Vps34-IN-1
  • Experimental Validation Results for Vps34-IN-1
  • Experimental Validation Results for Vps34-IN-1
  • Experimental Validation Results for Vps34-IN-1
  • Experimental Validation Results for Vps34-IN-1
CAS No.: 1383716-33-3
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  • Vps34-IN-1 Chemical Structure
    Vps34-IN-1 Chemical Structure
    1/16
  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Dec 18.

    Customer Validation
     VPS34-IN-1, VPS34-IN-2, PIK-III, and SAR405 (all 1 μM, 48 h) exhibited similar inhibition of 0.02 MOI WT SARS-CoV-2 infection in Vero E6 cells.

  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Dec 18.

    Customer Validation
     VPS34-IN-1, VPS34-IN-2, PIK-III, and SAR405 (all 1 μM, 48 h) protected cells from SARS-CoV-2-induced CPE, highlighting the critical role of VPS34 in SARS-CoV-2 infection.

  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Dec 18.

    Customer Validation
     Pharmacological profiling of VPS34 inhibitors against SARS-CoV-2 variants demonstrated that the EC50 of VPS34-IN-1 was 0.36, 0.99, 0.46, and 0.24 μM against WT, Beta, Delta, and Omicron variants, respectively.

  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Dec 18.

    Customer Validation
     Cytotoxicity assessments at 48 h in Vero E6 cells revealed that the CC50 values of VPS34-IN-1 was 11.00 μM.

  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2018 Jun 25;37(1):122. [Abstract]

    Customer Validation
     Huh7 and MHCC97H cells are treated with VPS34-IN1 for 24 h, and cell lysates are subjected to western blot analysis with the indicated antibodies.

  • 1/16

    Vps34-IN-1 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Aug 16;7(33):53515-53525. [Abstract]

    Customer Validation
     PI3KD/V-IN-01 affects autophagy HeLa cells are treated with different concentrations of PI3KD/V-IN-01, VPS34-IN-1, GDC-0941 or CAL-101 for 16 hours before they are fixed and stained for the autophagy marker LC3B.

  • Vps34-IN-1