AChE-IN-59
AChE-IN-59 (compounds 3b) is an AChE inhibitor, with an IC50 value of 0.05 μM. AChE-IN-59 can inhibit the aggregation of Aβ1-42, protect nerve cells and penetrate the blood-brain barrier well. AChE-IN-59 can be used for the research of Alzheimer's disease (AD).
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- CAS No.: 2957916-86-6
- Formule: C25H28N2O6
- Masse moléculaire:452.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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AChE 0.05 μM (IC50) |
BChE 4.68 μM (IC50) |
Aβ 1-42 |
AChE-IN-59 (compounds 3b) (50/100/500/1000 μg/ mL, 5 min) can inhibit the activity of ChEs, with the IC50 values for AChE and BuChE of 0.05 μM and 4.68 μM, respectively, indicating that AChE-IN-59 is selective for AChE subtype[1].
AChE-IN-59 (50/100/500/1000 μg/ mL, 5 min) shows well antioxidant activity in vitro in tests of Ferric ion reducing antioxidant power (FRAP) and DPPH free radical scavenging capacity[1].
AChE-IN-59 (25 µM, 5 min) has no cytotoxic effect on SH‐SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SH‐SY5Y
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Concentration:0/6.25/12.5/25/50/100 µM
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Incubation Time:5 h
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Result:Showed a good neuroprotective effect in the range of 6.25-25 µM and did not affect SH‐SY5Y cell viability below 25 µM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:zebrafish juveniles with 5 mg/L AlCl3 model[1]
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Dosage:5/10/25/50/100 μg/mL,
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Administration:Soak drug administration
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Result:Had certain therapeutic effect on AlCl3-induced zebrafish behavior inhibition, which was concentration-dependent. With the increase of compound concentration, the total distance of zebrafish larvae increased gradually.
Chemical Information
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CAS No. 2957916-86-6
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Masse moléculaire 452.50
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Formule C25H28N2O6
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SMILES
COC1=CC=C2C=C(C(OC2=C1)=O)NC(C3CCN(CC3)CC4=CC(OC)=CC(OC)=C4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-59 Related Classifications
HY-157978 Related Classifications
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