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Cat. No.: HY-P11846

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ADA2

ADA2 is an ADAMTS4-binding peptide and imaging agent with a human ADAMTS4 K_a of 5.3 nM and reduced renal uptake compared to related tracers. ADA2 accumulates in dilated aortic regions in aortic aneurysm mouse models. ADA2 exhibits an in vivo safety profile. ADA2 can be used for the research of aortic aneurysm.

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Formule: C₆₈H₁₁₈N₂₆O₂₈S₂
Masse moléculaire:1811.95

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

ADA2 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

ADAMTS4

In Vivo

[⁶⁸Ga]ADA2 (100 μCi; i.v.; single dose) achieves optimal aortic aneurysm uptake of 1.6% ID/g in Angiotensin-II-induced AA mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male, 8 weeks old, Angiotensin-II-induced aortic aneurysm model)^[1]
Dosage:

100 μCi
Administration:

i.v.; single dose
Result:

Exhibited the highest aortic aneurysm radioactivity uptake of 1.6% ID/g among tested tracers at 60 minutes post-injection.
Showed more pronounced uptake in the AA region.
Demonstrated low uptake in other major organs, including heart, liver, and lungs.

Chemical Information

Masse moléculaire 1811.95
Formule C₆₈H₁₁₈N₂₆O₂₈S₂
Sequence

Gly-{Lys(PEG2-DOTA)}-Gly-Gly-Ser-Gly-Gly-Ser-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
Sequence Shortening

G-{Lys(PEG2-DOTA)}-GGSGGS-cyclo(Cys-Ser-Arg-Arg-Gly-Cys) (Disulfide bridge: Cys9-Cys14)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Huang H, et al.. Synthesis and Evaluation of Cyclic Peptide-Based PET Tracers Targeting ADAMTS4 for Early Detection and Monitoring of Aortic Aneurysms. Journal of medicinal chemistry. 2025 Dec 11;68(23):25403-25415. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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