ADTL-EI1712
ADTL-EI1712 is a potent, orally active, and selective dual-target inhibitor of ERK1 and ERK5, inhibition rates of ERK1/5 at 1 μM are 93.54% and 89.35%, respectively. ADTL-EI1712 can induce regulated cell death, a form of cell death that relies on the activation of genetically encoded machinery, to overcome compensatory mechanism in specific cancer cells in vitro and in vivo.
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- CAS No.: 2414916-45-1
- Formule: C22H18Cl2N4O2S2
- Masse moléculaire:505.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>50 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| HL-60 | IC50 |
1.26 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
| MKN-74 | IC50 |
2.55 μM
Compound: 22ac; ADTL-EI1712
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Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs
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[PMID: 32078308] |
ADTL-EI1712 shows antiproliferative activity against HL-60, MKN-74 and HeLa cells, with IC50 values of 1.26+0.57, 2.55+0.66, >50 μM, respectively[1].
ADTL-EI1712 (0.5 μM, 24 h) induces regulated cell death accompanied by autophagy in MKN-74 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2414916-45-1
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Masse moléculaire 505.44
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Formule C22H18Cl2N4O2S2
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SMILES
O=C(C1=C(NC(C2=CC=CC=C2Cl)=O)SC3=C1CCN(C(NC4=CC=CC=C4Cl)=S)C3)N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ADTL-EI1712 Related Classifications
HY-138215 Related Classifications
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