(all-E)-UAB30
(all-E)-UAB30 (UAB30) is an retinoid X receptor (RXR) selective agonist.(all-E)-UAB30 shows anti-proliferation activity for MyLa, HuT 78, and HH cells with the IC50 of 34.7, 5.1, and 22.4 μM respectively.
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- CAS No.: 205252-59-1
- Formule: C20H22O2
- Masse moléculaire:294.39
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CV-1 | EC50 |
>2000 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
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[PMID: 9572893] |
| CV-1 | EC50 |
110 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR beta
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[PMID: 9572893] |
| CV-1 | EC50 |
370 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR gamma
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[PMID: 9572893] |
| CV-1 | EC50 |
>2000 nM
Compound: (all-E)-UAB30
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Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha
Transcriptional activation in CV-1 cells expressing retinoid A receptor RAR alpha
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[PMID: 9572893] |
| HL-60 | ED50 |
>10000 nM
Compound: (all-E)-UAB30
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Induction of HL-60 cells differentiation over 4 days
Induction of HL-60 cells differentiation over 4 days
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[PMID: 9572893] |
| NB-4 | ED50 |
>10000 nM
Compound: (all-E)-UAB30
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Induction of NB4 cell differentiation
Induction of NB4 cell differentiation
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[PMID: 9572893] |
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 205252-59-1
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Masse moléculaire 294.39
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Formule C20H22O2
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SMILES
O=C(O)/C=C(C)/C=C/C=C(C)/C=C1CCCC2=C\1C=CC=C2
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Synonyms
UAB30
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(all-E)-UAB30 Related Classifications
HY-117376 Related Classifications
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