Amorphin
Amorphin is a phosphorylase b with glycogen metabolism activity. Amorphin binds directly to alpha-actinin, with alpha-actinin mediating its binding to actin filaments. Amorphin can be used for the research of McArdle’s disease and breast cancer.
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- CAS No.: 4207-90-3
- Formule: C34H40O16
- Masse moléculaire:704.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Amorphin (Compound 7) (68 h) selectively inhibits the proliferation of MCF-7 human breast cancer cells with an IC50 of 0.95 μM, and has no effect on HCT-116 human colorectal cancer cells at concentrations up to 50 μM[1].
Amorphin (1 μg/mL; 2 h at 4°C) directly binds to biotinylated alpha-actinin in a solid-phase dot blot assay[2].
Amorphin (0.31-20 μg/mL; 15 min) binds with higher affinity to purified alpha-actinin than to purified F-actin in a solid-phase radioimmune assay[2].
Amorphin (0.5 mg/mL; 5 min) binds to actin filaments only when they are decorated with purified alpha-actinin, as observed via negative stain electron microscopy[2].
Amorphin binds specifically to the Z-bands of extracted glycerinated adult chicken pectoralis muscle myofibrils, restoring their electron-dense amorphous structure[2].
Amorphin partial peptide sequencing confirms it is nearly identical to rabbit phosphorylase b, demonstrating amorphin is a phosphorylase b[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4207-90-3
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Masse moléculaire 704.68
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Formule C34H40O16
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SMILES
O=C1C=2C(=C3C(O[C@@H](C(CO[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@@H](O)[C@H](O)[C@H]4O)=C)C3)=CC2)O[C@]6([C@@]1(C=7C(OC6)=CC(OC)=C(OC)C7)[H])[H]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Amorphin Related Classifications
HY-126756 Related Classifications
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