Anafiltamig
Based on 1 Customer Validation
Anafiltamig is a trivalent monoclonal antibody inhibitor targeting CD79B, CD3E and MS4A1. Anafiltamig consists of a humanized IgG1κ anti-CD79B arm and a bispecific scFv-based arm targeting CD3E and MS4A1. Anafiltamig simultaneously bridges T and B cells, activating T cells and specifically killing B cell tumors. Anafiltamig can be used for B cell malignancies such as non-Hodgkin lymphoma research.
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- Pureté: 96.59%
- CAS No.: 3009026-69-8
- Masse moléculaire:153.55 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
half-IGG1-kappa/(scFv-kappa-heavy)-h-CH2-CH3-(scFv-kappa-heavy)
Human
CD79B & CD3E &CD20/MS4A1
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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half-G1-kappa_scFvlh-h-CH2-CH3-scFvkh
ELISA, FACS, Functional assay
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Immobilized CD79 Protein, Human (HEK293, HY-P75386A) can bind Anafiltamig. The ED50 for this effect is 90.01 ng/mL. -
Immobilized CD3D-CD3E Heterodimer Protein, Human (HEK293, HY-P72726) can bind Anafiltamig. The ED50 for this effect is 83.32 ng/mL. -
Immobilized CD20/MS4A1 Protein, Human (HEK293, HY-P78543) can bind Anafiltamig. The ED50 for this effect is 917.4 ng/mL.
Chemical Information
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CAS No. 3009026-69-8
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Appearance Liquid
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Masse moléculaire 153.55 kDa
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Color Colorless to light yellow
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SMILES
N/A
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Synonyms
JNJ-80948543
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)