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Cat. No.: HY-149062

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Anticancer agent 102

Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis.

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CAS No.: 2914922-86-2
Formule: C₂₀H₁₉F₆N₃O
Masse moléculaire:431.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Anticancer agent 102 Chemical Structure

CAS No.: 2914922-86-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Anticancer agent 102 is a derivative of tetracaine. Anticancer agent 102 has anti-cancer activity. Anticancer agent 102 induces apoptosis^[1].

In Vitro

Anticancer agent 102 (compound 2s; 24 and 48 h) has antitumor activity with IC₅₀ values of 299.4 μM and 20.8 μM against Colo-205 and HepG2 cells, respectively^[1].
Anticancer agent 102 (25 µM and 50 µM; 24 h) down-regulates the expression level of apoptotic protein PI3K and FoXO3a, up-regulates the expression level of PTEN and FoXO1 in Colo-205 cells^[1].
Anticancer agent 102 (24 h) up-regulates Bax expression and induces caspase-3-dependent apoptosis in the HepG2 cell line^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^{[ 1]}

Cell Line:

Colo-205 and HepG2 cells
Concentration:

12.5, 25, 50, 100, 200, and 400 µM
Incubation Time:

24 and 48 hours
Result:

Inhibited cell growth in a dose-dependent manner.

Western Blot Analysis^{[ 1]}

Cell Line:

Colo-205 cells
Concentration:

25 µM and 50 µM
Incubation Time:

24 hours
Result:

down-regulated the expression level of apoptotic protein PI3K and FoXO3a, up-regulated the expression level of PTEN and FoXO1 in Colo-205 cells.

Chemical Information

CAS No. 2914922-86-2
Masse moléculaire 431.37
Formule C₂₀H₁₉F₆N₃O
SMILES

O=C(C1=CC=C(NCCCC)C=C1)N/N=C/C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. M İhsan Han, et al. Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones. ACS Omega. 2023 Feb 28;8(10):9198-9211. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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