Anticancer agent-371
Anticancer agent-371 is an anticancer compound that exerts antiproliferative and cytotoxic activity by inhibiting ABCC2 efflux transporter expression, inducing the integrated stress response and ER stress/unfolded protein response pathways, promoting amino acid deprivation and metabolic stress signaling, and reprogramming the long non-coding RNA landscape; it exhibits low toxicity to normal cells and can be used for research on pancreatic cancer, breast cancer, colorectal cancer, liver cancer, and ovarian cancer.
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- Formule: C25H28N2O3S
- Masse moléculaire:436.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3A | IC50 |
28.9 μM
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Cytotoxicity against human C3a hepatic cancer cells assessed as viability reduction incubated 48 hrs by SRB assay.
Cytotoxicity against human C3a hepatic cancer cells assessed as viability reduction incubated 48 hrs by SRB assay.
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42837737 |
| OVCAR-5 | IC50 |
19.2 μM
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Cytotoxicity against human OVCAR-5 ovarian cancer cells assessed as viability reduction incubated 24, 48, and 72 hrs by SRB assay.
Cytotoxicity against human OVCAR-5 ovarian cancer cells assessed as viability reduction incubated 24, 48, and 72 hrs by SRB assay.
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42837737 |
| MCF-10A | IC50 |
> 100 μM
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Cytotoxicity against normal human MCF10A mammary epithelial cells assessed as viability reduction with IC50 > 100 μM by SRB assay.
Cytotoxicity against normal human MCF10A mammary epithelial cells assessed as viability reduction with IC50 > 100 μM by SRB assay.
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42837737 |
In Vitro
Anticancer agent-371 (0.5-100 μM; 24-72 h) reduces the viability of pancreatic, liver, colorectal, breast, and ovarian cancer cell lines, with an IC50 of 28.9 μM against C3a hepatocytes and an IC50 of 19.2 μM against OVCAR-5 cells at 48 h[1].
Anticancer agent-371 (up to 100 μM) shows low cytotoxicity against normal MCF10A breast epithelial cells (IC50 >100 μM), which is lower than its cytotoxicity against cancer cell lines[1].
Anticancer agent-371 (10 μM; 24 h) induces an ISR-related transcriptomic program in SUIT-2 cells, including upregulation of DDIT4, CHAC1, TRIB3, SESN2, ASNS, and DDIT3, and downregulation of FXYD4, FLG, ABCC2, and TNFSF12-TNFSF13[1].
Anticancer agent-371 (10 μM; 24 h) reshapes the lncRNA profile of SUIT-2 cells, upregulating the stress-related LINC-PINT and suppressing oncogenic lncRNAs, including UCA1, DLEU1, and ZFAS1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 436.57
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Formule C25H28N2O3S
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SMILES
O=S(C1=CC=C(O)C(/C=N/C2=CC=C(C(C)C)C=C2)=C1)(NC3=CC=C(C(C)C)C=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent-371 Related Classifications
HY-190809 Related Classifications
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