Antitubercular agent-31
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC50 of 1.1 μM.
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- CAS No.: 2764818-29-1
- Formule: C20H24F2N4O5S2
- Masse moléculaire:502.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 1.1 μM (DprE1)[1]
Antitubercular agent-31 (Compound 2) shows aqueous solubility of 0.81 μg/mL in phosphate buffer pH 7.4. The plasma protein binding property is 97.9%[1].
Antitubercular agent-31 shows acceptable liver microsomal stability in human and mouse liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Balb/c mice[1]
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Dosage:10 mg/kg or 2 mg/kg
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Administration:Oral (10 mg/kg) or intravenous (2 mg/kg) administration (Pharmacokinetic Analysis)
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Result:PK data for Antitubercular agent-31 (Compound 2),iv, 2mg/kg[1].
Tmax (h) Cmax (ng/mL) AUC0-t
(h*ng/mL)AUC0-∞
(h*ng/mL)T1/2 (h) CL/F
(mL/h/kg)MRT0-∞
(h)0.1±0.0 463.4±103.4 158.2±18.8 161.3±18.6 0.3±0.0 12515.5±1379.7 0.4±0.0
No compound signal was detected at oral administration.
Chemical Information
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CAS No. 2764818-29-1
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Masse moléculaire 502.56
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Formule C20H24F2N4O5S2
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SMILES
O=C1N=C(N2CCN(CC3CCC(F)(F)CC3)CC2)SC4=C([N+]([O-])=O)C=C(S(=O)(C)=O)C=C14
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-31 Related Classifications
HY-151339 Related Classifications
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