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Cat. No.: HY-152232

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BChE-IN-15

BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent BChE inhibitor with an IC₅₀ of 1.76 nM against hBChE .

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CAS No.: 3060336-91-3
Formule: C₂₂H₃₃N₃O₂
Masse moléculaire:371.52

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

BChE-IN-15 Chemical Structure

CAS No.: 3060336-91-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BChE-IN-15 (Compound 6) is a pseudo-irreversible and covalent BChE inhibitor with an IC₅₀ of 1.76 nM against hBChE ^[1].

IC₅₀ & Target

^[1]

hBCHE

1.76 nM (IC₅₀)

hAChE

558.6 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	7.1 μM Compound: 6	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay	[PMID: 36586299]
SH-SY5Y	IC₅₀	5.8 μM Compound: 6	Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay Cytotoxicity against human SH-SY5Y cells assessed as inhibition of cell growth measured after 48 hrs by MTS assay	[PMID: 36586299]

In Vitro

BChE-IN-15 (Compound 6) (0.5-50 μM; 48 h) shows cytotoxicity against SH-SY5Y and HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SH-SY5Y and HepG2 cell lines
Concentration:

0.5-50 μM
Incubation Time:

48 h
Result:

Showed cytotoxicity with IC₅₀s of 5.8 μM and 7.1 μM against SH-SY5Y and HepG2 cells, respectively.

Chemical Information

CAS No. 3060336-91-3
Masse moléculaire 371.52
Formule C₂₂H₃₃N₃O₂
SMILES

CN(CC1=CNC2=C(C=CC=C12)OC(N(C)C)=O)CCC3CCCCCC3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Meden A, et al. Pseudo-irreversible butyrylcholinesterase inhibitors: Structure-activity relationships, computational and crystallographic study of the N-dialkyl O-arylcarbamate warhead. Eur J Med Chem. 2022 Dec 24;247:115048. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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