CCT369260
Based on 1 Customer Validation
CCT369260 (compound 1), a chemical probe, is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM.
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- Pureté: 99.67%
- CAS No.: 2647503-57-7
- Formule: C24H31ClF2N6O2
- Masse moléculaire:508.99
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 520 nM (BCL6)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OCI-Ly1 | DC50 |
0.049 μM
Compound: 1; CCT369260
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Induction of BCL6 degradation in human OCI-LY1 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay
Induction of BCL6 degradation in human OCI-LY1 cells incubated for 2 hrs by MSD electrochemiluminescent immunoassay
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[PMID: 32275432] |
| OCI-Ly1 | GI50 |
0.035 μM
Compound: 1; CCT369260
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Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY1 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
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[PMID: 32275432] |
| OCI-Ly3 | GI50 |
1.6 μM
Compound: 1; CCT369260
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Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human OCI-LY3 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
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[PMID: 32275432] |
| SUD4 | GI50 |
0.092 μM
Compound: 1; CCT369260
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Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
Antiproliferative activity agianst human SUDHL4 cells assessed as growth inhibition incubated for 14 days by CellTiter Glo reagent based assay
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[PMID: 32275432] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
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Dosage:15 mg/kg.
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Administration:PO, single dose.
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Result:Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
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Animal Model:Female Balb/C mice[1].
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Dosage:1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
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Administration:IV and PO
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Result:Demonstrated moderate clearance (CL 20 mL min−1 kg−1) with mean oral bioavailability of 54%.
Chemical Information
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CAS No. 2647503-57-7
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Appearance Solid
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Masse moléculaire 508.99
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Formule C24H31ClF2N6O2
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Color White to off-white
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SMILES
O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[C@@H](C)C(F)(F)[C@@H](C)C4)=NC=C3Cl)=CC=C2N1C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 300 mg/mL (589.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9647 mL | 9.8234 mL | 19.6468 mL | 49.1169 mL |
| 5 mM | 0.3929 mL | 1.9647 mL | 3.9294 mL | 9.8234 mL | |
| 10 mM | 0.1965 mL | 0.9823 mL | 1.9647 mL | 4.9117 mL | |
| 15 mM | 0.1310 mL | 0.6549 mL | 1.3098 mL | 3.2745 mL | |
| 20 mM | 0.0982 mL | 0.4912 mL | 0.9823 mL | 2.4558 mL | |
| 25 mM | 0.0786 mL | 0.3929 mL | 0.7859 mL | 1.9647 mL | |
| 30 mM | 0.0655 mL | 0.3274 mL | 0.6549 mL | 1.6372 mL | |
| 40 mM | 0.0491 mL | 0.2456 mL | 0.4912 mL | 1.2279 mL | |
| 50 mM | 0.0393 mL | 0.1965 mL | 0.3929 mL | 0.9823 mL | |
| 60 mM | 0.0327 mL | 0.1637 mL | 0.3274 mL | 0.8186 mL | |
| 80 mM | 0.0246 mL | 0.1228 mL | 0.2456 mL | 0.6140 mL | |
| 100 mM | 0.0196 mL | 0.0982 mL | 0.1965 mL | 0.4912 mL |
CCT369260 Related Classifications
HY-129188 Related Classifications
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