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Cat. No.: HY-120433

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BLT-3

BLT-3 is an inhibitor of scavenger receptor class B type I (SR-BI) that exerts reversible, non-cell-type-specific inhibitory effects on SR-BI-mediated lipid transport. BLT-3 inhibits SR-BI-mediated selective lipid uptake from HDL as well as cholesterol efflux from cells to HDL. BLT-3 enhances the binding of HDL to SR-BI. BLT-3 is applicable to research related to atherosclerosis and coronary heart disease.

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CAS No.: 109940-24-1
Formule: C₁₉H₁₃NO
Masse moléculaire:271.32

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Please store the product under the recommended conditions in the Certificate of Analysis.

BLT-3 Chemical Structure

CAS No.: 109940-24-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

In Vitro

BLT-3 inhibits SR-BI-mediated DiI uptake from DiI-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 0.51 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 2.3 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]CE uptake from [³H]CE-HDL in Y1-BS1 cells, with an IC₅₀ of 1.7 μM^[1].
BLT-3 inhibits SR-BI-mediated [³H]cholesterol efflux to HDL in ldlA[mSR-BI] cells, with an IC₅₀ of 17.2 μM^[1].
BLT-3 enhances the binding of ¹²⁵I-HDL to SR-BI in ldlA[mSR-BI] cells by increasing binding affinity (decreasing K_d and Koff) without altering Bmax, with an IC₅₀ of 46.5 μM for its binding-enhancing effect^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 109940-24-1
Masse moléculaire 271.32
Formule C₁₉H₁₃NO
SMILES

N=1OC(C=2C=CC=CC2)=C3C=CC=C3C1C=4C=CC=CC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002;99(24):15422-15427. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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