BMS-195270
Based on 1 Customer Validation
BMS-195270 is a small molecule that inhibits Carbachol (HY-B1208)-evoked tonicity of isolated rat bladder strips. BMS-195270 inhibits calcium flux.
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- Pureté : 97.52%
- CAS No.: 202822-23-9
- Formule: C15H9ClF3N3O2
- Masse moléculaire:355.70
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
BMS-195270 (3 μM) produces a dramatic reduction in developed pressure at infusion volumes of 0.2-1.3 mL and inhibits spontaneous contractions in an ex vivo rat whole bladder model[1].
BMS-195270 (2.8 mM) results adult worms of C. elegans displaying an Egl-d phenotype, as well as slowed or arrested pharyngeal pumping (Eat), and uncoordinated motion (Unc)[1].
BMS-195270 inhibits the response of HEK293 cells to the muscarinic agonist Carbachol (HY-B1208) with an EC50 of 2 μM[1].
BMS-195270 inhibits calcium flux, and retains inhibitory activity even when endogenous calcium channels are inactivated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 202822-23-9
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Appearance Solid
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Masse moléculaire 355.70
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Formule C15H9ClF3N3O2
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Color White to off-white
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SMILES
O=C1N(C2=CC(Cl)=CC=C2O)NC(C3=CC=CC=C3C(F)(F)F)=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (351.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8114 mL | 14.0568 mL | 28.1136 mL | 70.2839 mL |
| 5 mM | 0.5623 mL | 2.8114 mL | 5.6227 mL | 14.0568 mL | |
| 10 mM | 0.2811 mL | 1.4057 mL | 2.8114 mL | 7.0284 mL | |
| 15 mM | 0.1874 mL | 0.9371 mL | 1.8742 mL | 4.6856 mL | |
| 20 mM | 0.1406 mL | 0.7028 mL | 1.4057 mL | 3.5142 mL | |
| 25 mM | 0.1125 mL | 0.5623 mL | 1.1245 mL | 2.8114 mL | |
| 30 mM | 0.0937 mL | 0.4686 mL | 0.9371 mL | 2.3428 mL | |
| 40 mM | 0.0703 mL | 0.3514 mL | 0.7028 mL | 1.7571 mL | |
| 50 mM | 0.0562 mL | 0.2811 mL | 0.5623 mL | 1.4057 mL | |
| 60 mM | 0.0469 mL | 0.2343 mL | 0.4686 mL | 1.1714 mL | |
| 80 mM | 0.0351 mL | 0.1757 mL | 0.3514 mL | 0.8785 mL | |
| 100 mM | 0.0281 mL | 0.1406 mL | 0.2811 mL | 0.7028 mL |
BMS-195270 Related Classifications
HY-120620 Related Classifications
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