Catadegbrutinib
Based on 1 Customer Validation
BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC50=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma.
(Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.18%
- CAS No.: 2736508-60-2
- Formule: C47H54N12O4
- Masse moléculaire:851.01
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Stockage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCG mice treated REC-1 cancer cells[2]
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Dosage:6 mg/kg; 20 mg/kg
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Administration:p.o.
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Result:Exhibited dose-dependent tumor growth inhibition.
Caused greater inhibition of cell-cycle-related genes than BTK inhibitors and more effectively inhibited NFκB targets than BTK inhibitors.
Chemical Information
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CAS No. 2736508-60-2
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Appearance Solid
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Masse moléculaire 851.01
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Formule C47H54N12O4
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Color Light yellow to green yellow
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SMILES
CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
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Synonyms
BGB-16673; BTK-IN-29
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (146.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1751 mL | 5.8754 mL | 11.7507 mL | 29.3769 mL |
| 5 mM | 0.2350 mL | 1.1751 mL | 2.3501 mL | 5.8754 mL | |
| 10 mM | 0.1175 mL | 0.5875 mL | 1.1751 mL | 2.9377 mL | |
| 15 mM | 0.0783 mL | 0.3917 mL | 0.7834 mL | 1.9585 mL | |
| 20 mM | 0.0588 mL | 0.2938 mL | 0.5875 mL | 1.4688 mL | |
| 25 mM | 0.0470 mL | 0.2350 mL | 0.4700 mL | 1.1751 mL | |
| 30 mM | 0.0392 mL | 0.1958 mL | 0.3917 mL | 0.9792 mL | |
| 40 mM | 0.0294 mL | 0.1469 mL | 0.2938 mL | 0.7344 mL | |
| 50 mM | 0.0235 mL | 0.1175 mL | 0.2350 mL | 0.5875 mL | |
| 60 mM | 0.0196 mL | 0.0979 mL | 0.1958 mL | 0.4896 mL | |
| 80 mM | 0.0147 mL | 0.0734 mL | 0.1469 mL | 0.3672 mL | |
| 100 mM | 0.0118 mL | 0.0588 mL | 0.1175 mL | 0.2938 mL |
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