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Cat. No.: HY-157445

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CBR1-IN-3

CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM.

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CAS No.: 891101-69-2
Formule: C₁₆H₁₁ClN₂O₃
Masse moléculaire:314.72

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CBR1-IN-3 Chemical Structure

CAS No.: 891101-69-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM^[1].

IC₅₀ & Target

0.034 μM (CBR1)^[1]

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Cellular Effect

Cell Line	Type	Value	Description	References
CWR22R	IC₅₀	3.3 μM Compound: 2e	Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay Antagonistic activity at AR in human 22Rv1 cells assessed as reduction in cell number by CCK8 assay	[PMID: 32847363]

Chemical Information

CAS No. 891101-69-2
Masse moléculaire 314.72
Formule C₁₆H₁₁ClN₂O₃
SMILES

O=C(C(C1=N)=CC2=C(O1)C(O)=CC=C2)NC3=CC=CC=C3Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dawei Hu, et al. Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1. Org Biomol Chem. 2015 Jul 21;13(27):7487-99. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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CBR1-IN-3

Voir tous les produits spécifiques à Isoform NADPH Oxidase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CBR1-IN-3 Related Classifications

HY-157445 Related Classifications