Ceratamine A
Ceratamine A is an antimitotic heterocyclic alkaloid isolated from the marine sponge Pseudoceratina sp., acts as a microtubule-stabilizing agent. Ceratamine A exhibits cytotoxicity against human cancer cell lines.
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- CAS No.: 634151-15-8
- Formule: C17H16Br2N4O2
- Masse moléculaire:468.14
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
11.2 μM
Compound: Ceratamine A
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Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 29433924] |
| A549 | IC50 |
26.8 μM
Compound: Ceratamine A
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Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 29433924] |
| BGC-823 | IC50 |
20 μM
Compound: Ceratamine A
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Cytotoxicity against human BGC823 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human BGC823 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 29433924] |
| HCT-116 | IC50 |
12.4 μM
Compound: Ceratamine A
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Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 29433924] |
| HepG2 | IC50 |
7.8 μM
Compound: Ceratamine A
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Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
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[PMID: 29433924] |
| MCF7 | IC50 |
5 μg/mL
Compound: 1
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Antimitotic activity in human MCF7mp53 cells assessed as induction of mitotic arrest after 20 hrs
Antimitotic activity in human MCF7mp53 cells assessed as induction of mitotic arrest after 20 hrs
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[PMID: 20945907] |
Chemical Information
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CAS No. 634151-15-8
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Masse moléculaire 468.14
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Formule C17H16Br2N4O2
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SMILES
O=C(N(C)C=C1)C(CC2=CC(Br)=C(OC)C(Br)=C2)=C3C1=NC(NC)=N3
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Manzo E, et al. Ceratamines A and B, antimitotic heterocyclic alkaloids isolated from the marine sponge Pseudoceratina sp. collected in Papua New Guinea. Org Lett. 2003 Nov 27;5(24):4591-4. [Content Brief]
[2]. Nodwell M, et al. Synthetic approaches to the microtubule-stabilizing sponge alkaloid ceratamine A and desbromo analogues. J Org Chem. 2009 Feb 6;74(3):995-1006. [Content Brief]
[3]. Pan X, et al. Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A. Bioorg Med Chem Lett. 2018 Mar 1;28(5):866-868. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ceratamine A Related Classifications
HY-N6997 Related Classifications
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