CGP35348
Based on 2 publication(s) in Google Scholar
CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 123690-79-9
- Formule: C8H20NO4P
- Masse moléculaire:225.22
-
Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Membrane Transporter/Ion Channel Compound Library
HY-L011
-
Neuronal Signaling Compound Library
HY-L013
-
CNS-Penetrant Compound Library
HY-L028
-
Neurotransmitter Receptor Compound Library
HY-L062
-
Anti-Alzheimer's Disease Compound Library
HY-L069
-
Anti-Parkinson's Disease Compound Library
HY-L085
-
Neurodegenerative Disease-related Compound Library
HY-L086
-
GABA Receptor Compound Library
HY-L120
-
Human Metabolite Library
HY-L123
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Ion Channel Compound Library
HY-L166
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
Publications Citing Use of MedChemExpress (MCE) CGP35348
More
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Eight male Wistar rats[3]
-
Dosage:100, 300, and 900 mg/kg
-
Administration:Intraperitoneally given
-
Result:Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
Chemical Information
-
CAS No. 123690-79-9
-
Appearance Oil
-
Masse moléculaire 225.22
-
Formule C8H20NO4P
-
Color Off-white to light yellow
-
SMILES
O=P(C(OCC)OCC)(CCCN)O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Microbiol Res
Gut commensal Clostridium sporogenes-derived 5-aminovaleric acid attenuates liver injury by suppressing M1 macrophage activation in mice. [Abstract]2026 Jun:307:128477. PMID: 41793891 -
Cell Rep
Septo-subicular cholinergic circuit promotes seizure development via astrocytic inflammation. [Abstract]2025 May 14;44(5):115712. PMID: 40372911
Solvant et solubilité
H2O : 83.33 mg/mL (369.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (111.00 mM); Clear solution; Need ultrasonic
Pureté et documentation
-
Fiche technique (271 KB)
-
SDS (758 KB)
- English - EN (758 KB)
- Français - FR (758 KB)
- Deutsch - DE (758 KB)
- Norwegian - NO (758 KB)
- Español - ES (758 KB)
- Swedish - SV (758 KB)
- Italian - IT (758 KB)
- Korean - KR (758 KB)
- Portuguese - PT (758 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors [Content Brief]
[2]. Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. [Content Brief]
[3]. A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.4401 mL | 22.2005 mL | 44.4010 mL | 111.0026 mL |
| 5 mM | 0.8880 mL | 4.4401 mL | 8.8802 mL | 22.2005 mL | |
| 10 mM | 0.4440 mL | 2.2201 mL | 4.4401 mL | 11.1003 mL | |
| 15 mM | 0.2960 mL | 1.4800 mL | 2.9601 mL | 7.4002 mL | |
| 20 mM | 0.2220 mL | 1.1100 mL | 2.2201 mL | 5.5501 mL | |
| 25 mM | 0.1776 mL | 0.8880 mL | 1.7760 mL | 4.4401 mL | |
| 30 mM | 0.1480 mL | 0.7400 mL | 1.4800 mL | 3.7001 mL | |
| 40 mM | 0.1110 mL | 0.5550 mL | 1.1100 mL | 2.7751 mL | |
| 50 mM | 0.0888 mL | 0.4440 mL | 0.8880 mL | 2.2201 mL | |
| 60 mM | 0.0740 mL | 0.3700 mL | 0.7400 mL | 1.8500 mL | |
| 80 mM | 0.0555 mL | 0.2775 mL | 0.5550 mL | 1.3875 mL | |
| 100 mM | 0.0444 mL | 0.2220 mL | 0.4440 mL | 1.1100 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CGP35348 Related Classifications
HY-103530 Related Classifications
Powered by Bioz