Cinnabarin
Cinnabarin is a natural phenoxazinone red pigment derived from Pycnoporus sanguineus. Cinnabarin reduces rabies virus infection levels in neuroblastoma cells and causes cytopathic effects on neuroblastoma cell monolayers at high concentrations. Cinnabarin exhibits antibacterial activity against bacteria, with a preference for Gram-positive bacteria and human isolates. Cinnabarin can be used in studies related to rabies and drug-resistant Gram-positive bacteria.
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- CAS No.: 146-90-7
- Formule: C14H10N2O5
- Masse moléculaire:286.24
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Cinnabarin (0.155-5.0 mg/mL; 24 h) exhibits no cytotoxic effects on mouse neuroblastoma NA cells at 0.31 mg/mL or lower, but causes dose-dependent cytopathic effects at concentrations of 0.62 mg/mL and higher, affecting over 50% of cells at 2.5 mg/mL and above[1].
Cinnabarin (0.155-5.0 mg/mL; 24 h) reduces rabies virus infection in mouse neuroblastoma NA cells in a dose-dependent manner, achieving a four-fold reduction in viral titers at a concentration of 0.31 mg/mL; no viral titer results are reported for concentrations of 0.62 mg/mL and higher[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:mouse neuroblastoma NA cells (ATCC clone C-1300)
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Concentration:0.155 mg/mL, 0.31 mg/mL, 0.62 mg/mL, 1.25 mg/mL, 2.5 mg/mL, 5.0 mg/mL
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Incubation Time:24 h
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Result:Showed no effect on NA cell monolayers at concentrations up to 0.31 mg/mL.
Caused small cytopathic effects affecting 10% of cells at 0.62 mg/mL.
Induced cytopathic effects affecting 25% of cells at 1.25 mg/mL.
Provoked intense morphological alterations affecting more than 50% of cells at 2.5 mg/mL and 5.0 mg/mL.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss mice (male, 2 months old, 18-22 g)[1]
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Dosage:220 mg/kg; 380 mg/kg; 720 mg/kg; 1000 mg/kg
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Administration:i.p.; single dose
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Result:Caused no mortality in mice.
Showed no macroscopic or microscopic alterations (including inflammation, granulomas, or lesions) in liver, kidney, thymus, spleen, or heart tissue relative to vehicle controls.
Chemical Information
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CAS No. 146-90-7
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Masse moléculaire 286.24
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Formule C14H10N2O5
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SMILES
O=C(C(C1=NC2=C(CO)C=CC=C2OC1=C3)=C(N)C3=O)O
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cinnabarin Related Classifications
HY-N14107 Related Classifications
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