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Cat. No.: HY-12570

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CK2-IN-9

CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC₅₀ of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC₅₀ of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.

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CAS No.: 1461658-58-1
Formule: C₂₃H₂₉N₉O
Masse moléculaire:447.54

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CK2-IN-9 Chemical Structure

CAS No.: 1461658-58-1

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
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Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Casein Kinase :

Voir tous les produits spécifiques à Isoform Wnt :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	4 μM Compound: 7b	Inhibition of human ERG expressed in CHO cells by patch clamp assay Inhibition of human ERG expressed in CHO cells by patch clamp assay	[PMID: 26985319]
DLD-1	GI₅₀	0.08 μM Compound: 7b	Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay Antiproliferative activity against human DLD1 cells after 72 hrs by alamar blue assay	[PMID: 26985319]
HCT-116	GI₅₀	0.03 μM Compound: 7b	Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay Antiproliferative activity against human HTC116 cells after 72 hrs by alamar blue assay	[PMID: 26985319]
HCT-116	GI₅₀	0.03 μM Compound: Example 1	Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay Antiproliferative activity against human HCT116 cells after 72 hrs by Alamar blue assay	[PMID: 24900617]
Sf21	IC₅₀	<0.003 μM Compound: 7b	Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay	[PMID: 26985319]
SW-620	GI₅₀	0.03 μM Compound: 7b	Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay Antiproliferative activity against human SW620 cells after 72 hrs by alamar blue assay	[PMID: 26985319]

Chemical Information

CAS No. 1461658-58-1
Masse moléculaire 447.54
Formule C₂₃H₂₉N₉O
SMILES

O=C(C)NC1=CC(NC2=NC3=C(C#N)C=NN3C(NC4CC4)=C2)=CC=C1N(CCN(C)C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Dowling JE, et al. Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett. 2016 Jan 20;7(3):300-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
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Chemical Information
Pureté et documentation
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CK2-IN-9

Voir tous les produits spécifiques à Isoform Casein Kinase

Voir tous les produits spécifiques à Isoform Wnt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

CK2-IN-9 Related Classifications

HY-12570 Related Classifications