Conantokin R
Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity.
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- CAS No.: 202925-60-8
- Formule: C127H201N35O49S3
- Masse moléculaire:3098.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
IC50: 93 nM (NMDA receptor)[1]
Chemical Information
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CAS No. 202925-60-8
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Masse moléculaire 3098.35
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Formule C127H201N35O49S3
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Synonyms
Con-R
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Sequence
Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)
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Sequence Shortening
GE-{Gla}-{Gla}-VAKMAA-{Gla}-LAR-{Gla}-NIAKGCKVNCYP (Disulfide bridge:Cys21-Cys25)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. [Content Brief]
[2]. White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Conantokin R Related Classifications
HY-P1285 Related Classifications
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