CPP12 TFA
Based on 1 Customer Validation
CPP12 TFA is a small, amphipathic, cyclic cell-penetrating peptide (CPP). CPP12 TFA binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and then efficiently escapes from endosomes. CPP12 TFA can be used for the intracellular delivery of drugs and chemical probes.
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- Pureté: 99.83%
- Formule: C68H89F12N21O17
- Masse moléculaire:1700.55
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CPP12 (5 μM; 2 h) TFA exhibits high cytosolic entry efficiency in HeLa cells, serving as a 100% activity reference; its efficiency is reduced ~25-fold when serum concentration increases from 1% to 10% FBS[1].
CPP12 (5 μM; 2 h) TFA enters HeLa cells primarily via endocytosis followed by endosomal escape[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 1700.55
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Formule C68H89F12N21O17
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Color White to off-white
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Sequence
Cyclo(Phe-{d-Phe}-{2-Nal}-Arg-{d-Arg}-Arg-{d-Arg}-Gln)
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Sequence Shortening
Cyclo(F-{d-Phe}-{2-Nal}-R-{d-Arg}-R-{d-Arg}-Q)
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
H2O : ≥ 100 mg/mL (58.80 mM)
DMSO : ≥ 100 mg/mL (58.80 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.5880 mL | 2.9402 mL | 5.8805 mL | 14.7011 mL |
| 5 mM | 0.1176 mL | 0.5880 mL | 1.1761 mL | 2.9402 mL | |
| 10 mM | 0.0588 mL | 0.2940 mL | 0.5880 mL | 1.4701 mL | |
| 15 mM | 0.0392 mL | 0.1960 mL | 0.3920 mL | 0.9801 mL | |
| 20 mM | 0.0294 mL | 0.1470 mL | 0.2940 mL | 0.7351 mL | |
| 25 mM | 0.0235 mL | 0.1176 mL | 0.2352 mL | 0.5880 mL | |
| 30 mM | 0.0196 mL | 0.0980 mL | 0.1960 mL | 0.4900 mL | |
| 40 mM | 0.0147 mL | 0.0735 mL | 0.1470 mL | 0.3675 mL | |
| 50 mM | 0.0118 mL | 0.0588 mL | 0.1176 mL | 0.2940 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
CPP12 TFA Related Classifications
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