Cyanofenphos
Cyanofenphos is an orally active organophosphate insecticide and brain AChE inhibitor with neurotoxicity. Cyanofenphos induces delayed neurotoxicity such as ataxia and paralysis. Cyanofenphos also causes symptoms including somnolence, reduced feed intake and weight loss in hens. Cyanofenphos has a unique self-antagonistic effect: repeated low-dose pre-treatment not only reduces subsequent acute toxicity, but also exacerbates delayed neurotoxicity and attenuates enzyme inhibition, with the protective effect peaking at 24 h after the last pre-treatment. Cyanofenphos is commonly used in studies related to delayed neurotoxicity.
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- CAS No.: 13067-93-1
- Formule: C15H14NO2PS
- Masse moléculaire:303.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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AChE |
Cyanofenphos (80 mg/kg; oral; single dose) induces delayed neurotoxicity in hens following cyanofenphos challenge doses, with higher neurotoxicity incidence observed for 200 mg/kg compared to 100 mg/kg challenge doses[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Domestic hens (2-3 months old, body weight 1.30-2.00 kg)[2]
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Dosage:80 mg/kg (pretreatment); 100 mg/kg, 200 mg/kg (challenge)
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Administration:oral; single dose (pretreatment); oral; single dose (challenge, 24 hours or 8 days after pretreatment)
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Result:Resulted in 0 acute deaths and 20% (2/10 hens) developing slight ataxia for 100 mg/kg challenge at 24-hour interval.
Resulted in 0 acute deaths and 10% (1/10 hens) developing slight ataxia for 100 mg/kg challenge at 8-day interval.
Resulted in 0 acute deaths and 80% (8/10 hens) developing ataxia for 200 mg/kg challenge at 24-hour interval.
Resulted in 1 acute death and 89% (8/9 surviving hens) developing neurotoxicity for 200 mg/kg challenge at 8-day interval.
Chemical Information
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CAS No. 13067-93-1
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Masse moléculaire 303.32
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Formule C15H14NO2PS
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SMILES
N#CC1=CC=C(OP(=S)(OCC)C=2C=CC=CC2)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cyanofenphos Related Classifications
HY-120131 Related Classifications
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