DIZ-3
DIZ-3 is a selective multimeric G4 ligand based on a G4-ligand-dimerizing strategy. DIZ-3 intercalates into the G4-G4 interface, stabilizing the higher-order structure. DIZ-3 induces cell cycle arrest and apoptosis, and thus inhibits cell proliferation in alternative lengthening of telomere (ALT) cancer cells.
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- CAS No.: 2675490-72-7
- Formule: C46H44F2N8
- Masse moléculaire:746.89
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BJ | IC50 |
29.3 μM
Compound: DIZ-3
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Cytotoxicity against human BJ cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
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[PMID: 31759730] |
| U2OS | IC50 |
2.1 μM
Compound: DIZ-3
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
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[PMID: 31759730] |
DIZ-3 (0-40 μM; 24 hours) inhibits the proliferation in an ALT cancer cell line[1].
DIZ-3 (0.6-2.5 μM; 24 hours) induces U2OS cell cycle arrest and Apoptosis in ALT cancer cells[1].
DIZ-3 (0.12, 0.25, 0.5 μM; 7 days) causes colony formation and would healing assays carried out in U2OS cells[1].
DIZ-3 (0.12, 0.25, 0.5 μM; 24 h) significantly inhibits migration of U2OS cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human bone osteosarcoma U2OS cells, normal BJ fibroblasts
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Concentration:0-40 μM
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Incubation Time:24 hours
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Result:Caused a significant dose-dependent cytotoxic effect on U2OS cancer cells with an IC50 of 2.1 µM.
Induced much weaker growth inhibition on normal BJ fibroblasts with an IC50 of 29.3 µM.
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Cell Line:U2OS cells
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Concentration:0.6, 1.2, 2.5 μM
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Incubation Time:24 hours
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Result:Induced significant apoptosis in U2OS cells (the percentage of apoptotic cells increased from 10.1% to 24.9%).
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Cell Line:U2OS cells
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Concentration:0.6, 1.2, 2.5 μM
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Incubation Time:24 hours
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Result:Induced the apparent accumulation of cells in the S phase (increasing from 24.0% to 32.2%) in a dose-dependent manner.
Chemical Information
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CAS No. 2675490-72-7
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Masse moléculaire 746.89
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Formule C46H44F2N8
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SMILES
CN1CCN(CC1)C2=CC=C(C=C2)C3=C(NC(C4=CC=C(C=C4)C5=NC(C6=CC=C(C=C6)F)=C(N5)C7=CC=C(C=C7)N8CCN(CC8)C)=N3)C9=CC=C(C=C9)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DIZ-3 Related Classifications
HY-146812 Related Classifications
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