DMA-155
DMA-155 is an antiviral agent with binding activity against SARS-CoV-2 5'-terminal stem-loop RNAs, with affinities of 51.1 μM (SL1), 61.1 μM (SL4), 54.5 μM (SL5a), 66.9 μM (SL5b) and 48.6 μM (SL6), respectively. DMA-155 inhibits SARS-CoV-2 viral replication and reduces SARS-CoV-2 viral RNA levels. DMA-155 is applicable to the research of COVID-19.
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- CAS No.: 2237925-69-6
- Formule: C20H21N7O
- Masse moléculaire:375.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
DMA-155 (50-100 μM; 24 h) significantly inhibits human coronavirus OC43 replication in Vero E6 cells when administered at 50 μM or 100 μM for 24 hours[1].
DMA-155 (24-72 h) potently inhibits SARS-CoV-2 replication in Vero E6 cells with an IC50 of 16 μM at 24 hours post-infection, with sustained dose-dependent activity through 72 hours[1].
DMA-155 (10 μM; 72 h) inhibits SARS-CoV-2 replication in Vero E6 cells at 10 μM for 72 hours without significant cellular toxicity[1].
DMA-155 (0.1-100 μM; 2 days) specifically inhibits SARS-CoV-2 5'-UTR-dependent translation in Vero E6 cells, with a ~90% reduction in FLuc activity at 10 μM after 2 days of incubation, without non-specific effects on translation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2237925-69-6
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Masse moléculaire 375.43
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Formule C20H21N7O
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SMILES
O=C(C1=C(N)N=C(N(C)C)C(C2=CC=C(C3=CC=CC=C3)C=C2)=N1)NC(N)=N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DMA-155 Related Classifications
HY-179334 Related Classifications
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- DMA-155
- 2237925-69-6
- DMA155
- DMA 155
- SARS-CoV
- DNA/RNA Synthesis
- Vero E6 cells
- SARS-CoV-2 5'-end stem loop RNAs
- SARS-CoV-2 viral RNA
- SARS-CoV-2 5'-UTR-dependent translation
- SARS-CoV-2 5'-end SL4 RNA
- human coronavirus OC43
- SARS-CoV-2 5'-end SL5a RNA
- SARS-CoV-2 5'-end SL1 RNA
- SARS-CoV-2
- SARS-CoV-2 5'-end SL6 RNA
- Inhibitor
- inhibitor
- inhibit