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Cat. No.: HY-187474A

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DOPE-PEG2000-K237

Name: DOPE-PEG2000-K237
Brand: MedChemExpress
SKU: HY-187474A
Availability: PreOrder

(Synonyms: DOPE-PEG2000-Mal-Cys-HTMYYHHYQHHL)

DOPE-PEG2000-K237 (DOPE-PEG2000-Mal-Cys-HTMYYHHYQHHL) is an amphiphilic lipid-PEG-peptide conjugate composed of DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), PEG2000, and the K237 peptide (sequence: HTMYYHHYQHHL). K237 peptide is a tumor-homing peptide identified by phage display that specifically binds to vasculature in tumor tissues. DOPE-PEG2000-K237 is used for tumor-targeted drug delivery via functionalization of liposomes and nanoparticles.

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Please store the product under the recommended conditions in the Certificate of Analysis.

DOPE-PEG2000-K237 Chemical Structure

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Description

In Vitro

DOPE-PEG2000-K237: surface modification of liposomes and lipid nanoparticles for tumor vasculature-targeted drug delivery and anti-angiogenic research.
Structural composition:
(1) DOPE; a phospholipid with two oleoyl chains that inserts into lipid bilayers as a hydrophobic anchor and provides fusogenic activity for endosomal escape;
(2) PEG2000; a hydrophilic polymer chain that forms a steric barrier reducing opsonization and RES clearance, thereby extending blood circulation time;
(3) K237 peptide; a tumor-homing peptide identified through phage display screening that specifically recognizes and binds to angiogenic tumor vasculature, directing nanocarriers to tumor blood vessels for enhanced drug deposition at tumor sites and anti-angiogenic effects.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

SMILES

[DOPE-PEG2000-K237]
Synonyms

DOPE-PEG2000-Mal-Cys-HTMYYHHYQHHL
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.