ELQ-121
ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO)-site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research.
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- CAS No.: 1228283-36-0
- Formule: C17H21F2NO
- Masse moléculaire:293.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
Chemical Information
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CAS No. 1228283-36-0
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Masse moléculaire 293.35
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Formule C17H21F2NO
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SMILES
FC1=C2C(NC(C)=C(CCCCCCC)C2=O)=CC(F)=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Probst, A. S., et al., (2025). In vivo screen of Plasmodium targets for mosquito-based malaria control. Nature. Advance online publication. [Content Brief]
[2]. Eberhard, N., et al., (2020). Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites. Frontiers in veterinary science, 7, 96. [Content Brief]
[3]. Winter, R., et al., (2011). Optimization of endochin-like quinolones for antimalarial activity. Experimental parasitology, 127(2), 545–551. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ELQ-121 Related Classifications
HY-174343 Related Classifications
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