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Cat. No.: HY-10535R

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Evofosfamide (Standard)

(Synonyms: TH-302 (Standard))

Evofosfamide (Standard) is the analytical standard of Evofosfamide (HY-10535). This product is intended for research and analytical applications. Evofosfamide (TH-302) is a hypoxia-activated proagent with IC₅₀ of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 918633-87-1
Formule: C₉H₁₆Br₂N₅O₄P
Masse moléculaire:449.04

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Evofosfamide (Standard) Chemical Structure

CAS No.: 918633-87-1

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Product Information
- Information
- Application
Chemical Information
Pureté et documentation
Calculators
Help & FAQs
Classifications
Bioz

Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 918633-87-1
Masse moléculaire 449.04
Formule C₉H₁₆Br₂N₅O₄P
SMILES

O=P(NCCBr)(OCC1=CN=C(N1C)[N+]([O-])=O)NCCBr
Synonyms

TH-302 (Standard)
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Meng F, et al. Enhancement of hypoxia-activated prodrug TH-302 anti-tumor activity by Chk1 inhibition. BMC Cancer. 2015 May 21;15:422. [Content Brief]

[2]. Zhang X, et al. MR Imaging Biomarkers to Monitor Early Response to Hypoxia-Activated Prodrug TH-302 in Pancreatic Cancer Xenografts. PLoS One. 2016 May 26;11(5):e0155289. [Content Brief]

[3]. Peeters SG, et al. TH-302 in Combination with Radiotherapy Enhances the Therapeutic Outcome and Is Associated with Pretreatment [¹⁸F]HX4 Hypoxia PET Imaging. Clin Cancer Res. 2015 Jul 1;21(13):2984-92. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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