FAPI-46
Based on 3 publication(s) in Google Scholar
FAPI-46 is a quinoline-based fibroblast activation protein (FAP)-targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation.
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- Pureté: 99.02%
- CAS No.: 2374782-04-2
- Formule: C41H57F2N11O9
- Masse moléculaire:885.96
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) FAPI-46
More
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
Activité biologique
fibroblast activation protein (FAP)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2374782-04-2
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Appearance Solid
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Masse moléculaire 885.96
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Formule C41H57F2N11O9
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Color Light yellow to yellow
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SMILES
O=C(C1=CC=NC(C=C2)=C1C=C2N(C)CCCN(CC3)CCN3C(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)NCC(N(CC5(F)F)[C@@H](C5)C#N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Pharmaceuticals (Basel)
Bridging Research and Clinical Practice: Automated [68Ga]Ga-FAPi-46 Synthesis and Quality Control for Oncological PET Imaging. [Abstract]2026 Apr 8;19(4):594. PMID: 42075850 -
Nucl Med Biol
Illuminating radionuclide therapy response: Monitoring cancer cell and CAF survival in a direct 2D co-culture model. [Abstract]2025 Oct 10:150-151:109571. PMID: 41108813
FAPI-46 purchased from MedChemExpress. Usage Cited in: Nucl Med Biol. 2025 Oct 10:150-151:109571. [Abstract]
Radiotracer uptake studies in the applied cell lines. Specific uptake of 1 nM [111In]In-FAPI-46 by PS-1-CBG99-RFP (n = 4), Panc-1-CBR2-GFP (n = 2), 19T-TF-CBG99-RFP (n = 3), and T47D-CBR2-GFP (n = 2). %AA = percentage added dose, BC = breast cancer, PDAC = pancreatic ductal adenocarcinoma.
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Appl Radiat Isot
[68Ga]Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions. [Abstract]2024 Apr:206:111211. PMID: 38309117
FAPI-46 purchased from MedChemExpress. Usage Cited in: Appl Radiat Isot. 2024 Apr:206:111211. [Abstract]
Mean RCP and RCY values obtained by TLC and HPLC during the study of the influence of the reaction buffer on the radiolabeling of [68Ga]Ga-FAPI-46.
FAPI-46 purchased from MedChemExpress. Usage Cited in: Appl Radiat Isot. 2024 Apr:206:111211. [Abstract]
Radio-TLC spectra of [68Ga]Ga-FAPI-46 after radiolabeling with HEPES 0.3 M or with HEPES 0.3 M + gentisic acid 0.6 mg/mL and elution of the TLC plate with aqueous 0.1 M sodium citrate pH 5 or with aqueous 1 M ammonium acetate in methanol (1:1).
Solvant et solubilité
H2O : 100 mg/mL (112.87 mM; Need ultrasonic)
DMSO : 100 mg/mL (112.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5.75 mg/mL (6.49 mM); Clear solution
This protocol yields a clear solution of ≥ 5.75 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (57.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (5.64 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429. [Content Brief]
[2]. Moon ES, et, al. Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 1.1287 mL | 5.6436 mL | 11.2872 mL | 28.2180 mL |
| 5 mM | 0.2257 mL | 1.1287 mL | 2.2574 mL | 5.6436 mL | |
| 10 mM | 0.1129 mL | 0.5644 mL | 1.1287 mL | 2.8218 mL | |
| 15 mM | 0.0752 mL | 0.3762 mL | 0.7525 mL | 1.8812 mL | |
| 20 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4109 mL | |
| 25 mM | 0.0451 mL | 0.2257 mL | 0.4515 mL | 1.1287 mL | |
| 30 mM | 0.0376 mL | 0.1881 mL | 0.3762 mL | 0.9406 mL | |
| 40 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7054 mL | |
| 50 mM | 0.0226 mL | 0.1129 mL | 0.2257 mL | 0.5644 mL | |
| 60 mM | 0.0188 mL | 0.0941 mL | 0.1881 mL | 0.4703 mL | |
| 80 mM | 0.0141 mL | 0.0705 mL | 0.1411 mL | 0.3527 mL | |
| 100 mM | 0.0113 mL | 0.0564 mL | 0.1129 mL | 0.2822 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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