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Cat. No.: HY-13635A

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Finasteride acetate

Name: Finasteride acetate
Brand: MedChemExpress
SKU: HY-13635A
Availability: PreOrder

(Synonyms: MK-906 acetate)

4 Cited Publications

Avis client

Based on 4 publication(s) in Google Scholar

Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 222989-99-3
Formule: C₂₅H₄₀N₂O₄
Masse moléculaire:432.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Finasteride acetate Chemical Structure

CAS No.: 222989-99-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

IC50: 4.2 nM (type II 5α-reductase)^[1]

In Vitro

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells^[2].
Finasteride decreases the conversion of [³H]testosterone (T) to [³H]dihydrotestosterone (DHT) in P. crustosum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

PC-3, DU-145, and LNCaP cells
Concentration:

10 μM
Incubation Time:

6, 12, 24 h
Result:

Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells.
Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.

In Vivo

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)^[3]
Dosage:

0.1-0.5 mg/kg
Administration:

P.o. once daily for 16 weeks
Result:

Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%).
Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration.
No adverse effects on dogs.

Chemical Information

CAS No. 222989-99-3
Masse moléculaire 432.60
Formule C₂₅H₄₀N₂O₄
SMILES

CC(O)=O.C[C@@]1([C@H]2C(NC(C)(C)C)=O)[C@](CC2)([H])[C@@](CC[C@](N3)([H])[C@@]4(C=CC3=O)C)([H])[C@]4([H])CC1
Synonyms

MK-906 acetate
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

All In Vivo Efficacy StudyWBCell Proliferation/Viability Assay

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Journal Impact Factor

Phytomedicine

Bushen Tongluo formula ameliorated testosterone propionate-induced benign prostatic hyperplasia in rats. [Abstract]

2023 Nov:120:155048. PMID: 37651753

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased the prostate volume, wet weight, and prostate index of TP-induced BPH rats.

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Protein levels of TGF-β1, vimentin, and E-cadherin were detected by western blot analysis. Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased TGF-β1 expression in the prostate tissues of BPH rats.

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d)-spiked serum significantly inhibited the activities of BPH-1 cells at 48, 72, and 96 h compared to the serum of the model group.
J Transl Med

The soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling. [Abstract]

2023 Feb 2;21(1):71. PMID: 36732752

Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]

Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the analgesic effects of TPPU in anhedonia-susceptible mice.

Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]

TSPO antagonist Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the antidepressant effects of TPPU in anhedonia-susceptible mice.
Sci Rep

Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5α-Reductase. [Abstract]

2019 Dec 23;9(1):19703. PMID: 31873149
J Pain

Alleviation of Mechanical Allodynia by 14,15-Epoxyeicosatrienoic Acid in a Central Poststroke Pain Model: Possible Role of Allopregnanolone and δ-Subunit-Containing Gamma-Aminobutyric Acid A Receptors. [Abstract]

2019 May;20(5):577-591. PMID: 30500366

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Flores E, et, al. Steroid 5alpha-reductase inhibitors. Mini Rev Med Chem. 2003 May;3(3):225-37. [Content Brief]

[2]. Yun DK, et, al. Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence. Biomol Ther (Seoul). 2013 Jan;21(1):49-53. [Content Brief]

[3]. Sirinarumitr K, et, al. Effects of finasteride on size of the prostate gland and semen quality in dogs with benign prostatic hypertrophy. J Am Vet Med Assoc. 2001 Apr 15;218(8):1275-80. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Finasteride acetate

4 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Pureté et documentation
Références

1/16
1/16

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Customer Validation
Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased the prostate volume, wet weight, and prostate index of TP-induced BPH rats.
1/16

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Customer Validation
Protein levels of TGF-β1, vimentin, and E-cadherin were detected by western blot analysis. Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d) significantly decreased TGF-β1 expression in the prostate tissues of BPH rats.
1/16

Finasteride acetate purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Nov:120:155048. [Abstract]

Customer Validation
Finasteride (Proscar) (0.5 mg/kg; i.g.; once daily for 28 d)-spiked serum significantly inhibited the activities of BPH-1 cells at 48, 72, and 96 h compared to the serum of the model group.
1/16

Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]

Customer Validation
Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the analgesic effects of TPPU in anhedonia-susceptible mice.
1/16

Finasteride acetate purchased from MedChemExpress. Usage Cited in: J Transl Med. 2023 Feb 2;21(1):71. [Abstract]

Customer Validation
TSPO antagonist Finasteride (Fina) (10 mg/kg; p.o.; once daily for 7 d) attenuated the antidepressant effects of TPPU in anhedonia-susceptible mice.

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Finasteride acetate

Publications Citing Use of MedChemExpress (MCE) Finasteride acetate