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BEGAIN - brain enriched guanylate kinase associated Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57596

About BEGAIN

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:100,537,147-100,587,417 (from NCBI)

This gene has 11 transcripts (splice variants) and 116 orthologues. Broad expression in brain (RPKM 1.4), adrenal (RPKM 0.4) and 14 other tissues.

Summary

Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to act upstream of or within evoked excitatory postsynaptic potential. Predicted to be located in dendrite; nucleus; and presynapse. Predicted to be active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

BEGAIN Products (25)

mRNA	Protein	Name
NM_001159531.2	NP_001153003.1	brain-enriched guanylate kinase-associated protein isoform 1
NM_001385082.1	NP_001372011.1	brain-enriched guanylate kinase-associated protein isoform 1
NM_001385083.1	NP_001372012.1	brain-enriched guanylate kinase-associated protein isoform 1
NM_001385084.1	NP_001372013.1	brain-enriched guanylate kinase-associated protein isoform 1
NM_001385085.1	NP_001372014.1	brain-enriched guanylate kinase-associated protein isoform 2
NM_001385086.1	NP_001372015.1	brain-enriched guanylate kinase-associated protein isoform 3
NM_001385087.1	NP_001372016.1	brain-enriched guanylate kinase-associated protein isoform 4
NM_001385088.1	NP_001372017.1	brain-enriched guanylate kinase-associated protein isoform 5
NM_001385089.1	NP_001372018.1	brain-enriched guanylate kinase-associated protein isoform 6
NM_001385090.1	NP_001372019.1	brain-enriched guanylate kinase-associated protein isoform 7
NM_001385091.1	NP_001372020.1	brain-enriched guanylate kinase-associated protein isoform 8
NM_001385092.1	NP_001372021.1	brain-enriched guanylate kinase-associated protein isoform 9
NM_001385093.1	NP_001372022.1	brain-enriched guanylate kinase-associated protein isoform 10
NM_001385094.1	NP_001372023.1	brain-enriched guanylate kinase-associated protein isoform 11
NM_001385095.1	NP_001372024.1	brain-enriched guanylate kinase-associated protein isoform 12
NM_001385096.1	NP_001372025.1	brain-enriched guanylate kinase-associated protein isoform 13
NM_001385097.1	NP_001372026.1	brain-enriched guanylate kinase-associated protein isoform 13
NM_001385098.1	NP_001372027.1	brain-enriched guanylate kinase-associated protein isoform 13
NM_001385099.1	NP_001372028.1	brain-enriched guanylate kinase-associated protein isoform 13
NM_001385100.1	NP_001372029.1	brain-enriched guanylate kinase-associated protein isoform 13
NM_001385101.1	NP_001372030.1	brain-enriched guanylate kinase-associated protein isoform 14
NM_001385102.1	NP_001372031.1	brain-enriched guanylate kinase-associated protein isoform 14
NM_001385103.1	NP_001372032.1	brain-enriched guanylate kinase-associated protein isoform 14
NM_001385104.1	NP_001372033.1	brain-enriched guanylate kinase-associated protein isoform 14
NM_020836.4	NP_065887.1	brain-enriched guanylate kinase-associated protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
brain-enriched guanylate kinase-associated protein	brain-enriched guanylate kinase-associated homolog

BEGAIN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	BEGAIN	Q9BUH8	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	25416956
Intra	BEGAIN	Q9BUH8	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	25416956
Intra	BEGAIN	Q9BUH8	ZNF319	Homo sapiens	Q9P2F9	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	ZNF417	Homo sapiens	Q8TAU3	Y2H Pooling	16189514
Intra	BEGAIN	Q9BUH8	ENKD1	Homo sapiens	Q9H0I2	Y2H Pooling	16189514
Intra	BEGAIN	Q9BUH8	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	BEGAIN	Q9BUH8	RBL1	Homo sapiens	P28749	Pull Down	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 4, Multiple Types	Cataract 4 Multiple Types CTRCT4 Cca3 Pcc Aculeiform Cataract Cataract 4, Multiple Types, With Or Without Microcornea Cataract, Crystalline Aculeiform Caca Cataract, Congenital, Cerulean Type, 3 Congenital Cataract Cerulean Type 3 Cataract Congenital Dominant Non Nuclear Ccp Cataract, Nonnuclear Polymorphic Congenital Cataract, Punctate, Progressive Juvenile-Onset Cataract 4 Multiple Types With Or Without Microcornea Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract Cataract, Polymorphic Congenital Congenital Cataract Blue Dot Type 3 Congenital Non-Nuclear Polymorphic Cataract Crystalline Aculeiform Cataract Punctate, Progressive Juvenile-Onset, Cataract Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Developmental And Epileptic Encephalopathy 66	DEE66 Epileptic Encephalopathy, Early Infantile, 66 Eiee66 Developmental And Epileptic Encephalopathy, 66 Early Infantile Epileptic Encephalopathy 66 Encephalopathy, Epileptic, Early Infantile, Type 66
Kagami-Ogata Syndrome	Paternal Uniparental Disomy Of Chromosome 14 Uniparental Disomy, Paternal, Chromosome 14 Kos Mca Due To 14q32.2 Maternally Expressed Gene Defect Paternal Uniparental Disomy 14 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion Maternal Del(14)(Q32.2) Maternal Monosomy 14q32.2 Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14 Upd(14)Pat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01467	BEGAIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BEGAIN	RGD	RGD:708347
Canis familiaris	BEGAIN	VGNC	VGNC:38429
Felis catus	BEGAIN	VGNC	VGNC:60100
Bos taurus	BEGAIN	VGNC	VGNC:26465
Mus musculus	BEGAIN	MGD	MGI:3044626
Macaca mulatta	BEGAIN	VGNC	VGNC:70124
Others	BEGAIN	NCBI