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Vps35 - VPS35 retromer complex component Gene

Also Known as Mem3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 65114

Summary

Enables D1 Dopamine Receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neurotransmitter receptor transport, endosome to postsynaptic membrane; and positive regulation of cell communication. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and postsynaptic density. Part of retromer complex. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Parkinson's disease 17. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]

Vps35 Products (1)

mRNA	Protein	Name
NM_022997.5	NP_075373.1	vacuolar protein sorting-associated protein 35

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	27460146	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15965486	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	30155515	MGI
involved in modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	30155515	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	30155515	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in negative regulation of lysosomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in negative regulation of protein homooligomerization	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in negative regulation of protein localization	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in neurotransmitter receptor transport, endosome to plasma membrane	IMP IMP: Inferred from mutant phenotype	27460146	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	28384478	MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	28384478	MGI
involved in positive regulation of Wnt protein secretion	IMP IMP: Inferred from mutant phenotype	18160348	MGI
involved in positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17239604	MGI
involved in positive regulation of dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in positive regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in protein localization to organelle	IMP IMP: Inferred from mutant phenotype	26203154	MGI
involved in regulation of postsynapse assembly	IDA IDA: Inferred from direct assay	26521016	MGI
involved in regulation of postsynapse assembly	IMP IMP: Inferred from mutant phenotype	26521016	MGI
involved in regulation of synapse maturation	IDA IDA: Inferred from direct assay	26521016	MGI
involved in regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	26521016	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	28384478	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	28384478	MGI
involved in voluntary musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	26203154	MGI

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17239604	MGI
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	26203154	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	30155515	MGI
is active in dopaminergic synapse	IEP IEP: Inferred from expression pattern	30155515	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	30155515	MGI
located in endosome	IDA IDA: Inferred from direct assay	26965651	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26521016	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	26521016	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26521016	MGI
located in neuron projection	IMP IMP: Inferred from mutant phenotype	26203154	MGI
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	26203154	MGI
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	26203154	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	26521016	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	26521016	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	26521016	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	29445238	MGI
part of retromer complex	IDA IDA: Inferred from direct assay	21040701	MGI
located in synapse	IDA IDA: Inferred from direct assay	29118110	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
vacuolar protein sorting-associated protein 35	maternal embryonic message 3 vesicle protein sorting 35

Vps35 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	Vps35	Q9EQH3	Vps26a	Mus musculus	P40336-1	Pull Down	15965486
Intra	Vps35	Q9EQH3	Vps29	Mus musculus	Q9QZ88-1	Pull Down	15965486
Cross	Vps35	Q9EQH3	FKBP15	Homo sapiens	Q5T1M5	Anti Tag CoIP	20923837
Cross	Vps35	Q9EQH3	FKBP15	Homo sapiens	Q5T1M5	Y2H	20923837
Intra	Vps35	Q9EQH3	Sort1	Mus musculus	Q6PHU5	Anti Bait CoIP	18480253
Intra	Vps35	Q9EQH3	Sorl1	Mus musculus	O88307	Anti Bait CoIP	18480253
Intra	Vps35	Q9EQH3	Vps29	Mus musculus	Q9QZ88	Anti Bait CoIP	21040701

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P11345	VPS35 c-terminal peptide		97.75%	Unkown
HY-RS15685	VPS35 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15686	VPS35L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21083	Vps35 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27600	Vps35 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vps35	NCBI	NCBI:55737