Sort1 - sortilin 1 Gene

Also Known as Ntr3; Ntsr3; 2900053A11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20661

Summary

Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and Neurotensin Receptor activity, non-G protein-coupled. Involved in several processes, including glucose import; myotube differentiation; and response to Insulin. Acts upstream of or within endocytosis; negative regulation of fat cell differentiation; and protein targeting to lysosome. Located in cytoplasmic vesicle membrane; plasma membrane; and trans-Golgi network transport vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and genitourinary system. Orthologous to human SORT1 (sortilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sort1 Products (2)

mRNA Protein Name
NM_001271599.1 NP_001258528.1 sortilin isoform 1 precursor
NM_019972.3 NP_064356.2 sortilin isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18480253 MGI
Biological Process GO Annotation Evidence References Source
involved in D-glucose import IMP
IMP: Inferred from mutant phenotype
15992544 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
24163244 MGI
involved in maintenance of synapse structure IDA
IDA: Inferred from direct assay
29398357 MGI
involved in maintenance of synapse structure IMP
IMP: Inferred from mutant phenotype
29398357 MGI
involved in myotube differentiation IMP
IMP: Inferred from mutant phenotype
18258592 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
24928897 MGI
acts upstream of or within protein targeting to lysosome IMP
IMP: Inferred from mutant phenotype
19732768 MGI
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
15992544 MGI
involved in vesicle organization IMP
IMP: Inferred from mutant phenotype
15992544 MGI
Cellular Component GO Annotation Evidence References Source
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
29398357 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
29398357 MGI
located in cytoplasmic vesicle membrane IDA
IDA: Inferred from direct assay
12490950 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15992544 MGI
located in trans-Golgi network transport vesicle IDA
IDA: Inferred from direct assay
15078902 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sortilin

  • mNTR3

  • neurotensin receptor 3

Sort1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sort1 Q6PHU5 Nradd Mus musculus Q8CJ26
IF
19407813
Intra
Sort1 Q6PHU5 Kcnk2 Mus musculus P97438
Anti Bait CoIP
20405001
Intra
Sort1 Q6PHU5 Vps35 Mus musculus Q9EQH3
Anti Bait CoIP
21040701
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120821 Endosidin-2 Inhibitor 99.17% Unkown
HY-153686 BVFP Inhibitor 98.12% Unkown
HY-D1581 BODIPY 505/515-8-C3-COOH 99.92% Unkown
HY-W747072 3-Sulfo-taurocholic Acid Disodium Salt 99.9% Unkown
HY-132975 PrDiAzK Inhibitor 99.52% Unkown
HY-RS13575 SORT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153687 SORT-PGRN interaction inhibitor 2 Inhibitor / Unkown
HY-159868 SORT1-IN-1 Inhibitor / Unkown
HY-159875 SORT1-IN-2 Inhibitor / Unkown
HY-159876 SORT1-IN-3 Inhibitor / Unkown
HY-159877 SORT1-IN-4 Inhibitor / Unkown
HY-159878 SORT1-IN-5 Inhibitor / Unkown
HY-RS21049 Sort1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27567 Sort1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sort1 NCBI NCBI:6272