AACS - acetoacetyl-CoA synthetase Gene

Also Known as ACSF1; SUR-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65985

About AACS

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:125,065,435-125,143,316 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 23.3), skin (RPKM 16.5) and 24 other tissues.

Summary

Predicted to enable acetoacetate-CoA Ligase activity. Predicted to be involved in positive regulation of Insulin secretion. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AACS Products (7)

mRNA Protein Name
NM_001319839.2 NP_001306768.1 acetoacetyl-CoA synthetase isoform 2
NM_001319840.2 NP_001306769.1 acetoacetyl-CoA synthetase isoform 3
NM_001414675.1 NP_001401604.1 acetoacetyl-CoA synthetase isoform 4
NM_001414676.1 NP_001401605.1 acetoacetyl-CoA synthetase isoform 5
NM_001414677.1 NP_001401606.1 acetoacetyl-CoA synthetase isoform 6
NM_001414678.1 NP_001401607.1 acetoacetyl-CoA synthetase isoform 7
NM_023928.5 NP_076417.2 acetoacetyl-CoA synthetase isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AACS Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (109 - 544)

  • 0
  • 200
  • 400
  • 600
  • 672 a.a.
Protein Preferred Names Protein Names

acetoacetyl-CoA synthetase

  • acetoacetate-CoA ligase

AACS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
AACS Q86V21 CMTM5 Homo sapiens Q96DZ9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AACS Proteins

Cat. No. Nom du produit Accession Pureté
HY-P74435 AACS Protein, Human (sf9, His) Q86V21-1 (M1-F672) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Atrial Septal Defect 8

  • ASD8

  • Atrial Heart Septal Defect 8

  • Septal Defect, Atrial, Type 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B0124 Zonisamide Inhibitor 99.95% Yes
HY-B0124A Zonisamide sodium Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-14880B Bavisant dihydrochloride hydrate Antagonist 98.07% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-171414 MC-VC-PAB-O-Gemcitabine 99.24% Unkown
HY-161886 SMARCA2-IN-7 Inhibitor / Unkown
HY-161887 SMARCA2-IN-8 Inhibitor / Unkown
HY-B0124S3 Zonisamide-15N,d4 / Unkown
HY-RS00016 AACS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182157 AAC Trimer phosphoramidite / Unkown
HY-B0124S2 Zonisamide-13C6 Inhibitor / Unkown
HY-RS22091 Aacs Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28611 Aacs Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AACS VGNC VGNC:37403
Mus musculus AACS MGD MGI:1926144
Rattus norvegicus AACS RGD RGD:708522
Felis catus AACS VGNC VGNC:59448
Bos taurus AACS VGNC VGNC:25438
Macaca mulatta AACS VGNC VGNC:97730
Others AACS NCBI