SNRPC - small nuclear ribonucleoprotein polypeptide C Gene

Also Known as U1C; Yhc1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6631

About SNRPC

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,757,505-34,773,857 (from NCBI)

This gene has 4 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in testis (RPKM 34.9), bone marrow (RPKM 32.7) and 25 other tissues.

Summary

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.[provided by RefSeq, Oct 2009]

SNRPC Products (1)

mRNA Protein Name
NM_003093.3 NP_003084.1 U1 small nuclear ribonucleoprotein C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
NOT enables U1 snRNA binding IDA
IDA: Inferred from direct assay
1826349 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8076607 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
8532530 GOA
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
8798632 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
15312772 GOA
Biological Process GO Annotation Evidence Références Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
8972845 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
8972845 GOA
Cellular Component GO Annotation Evidence Références Source
located in Cajal body IDA
IDA: Inferred from direct assay
10068039 GOA
part of U1 snRNP IDA
IDA: Inferred from direct assay
15312772 GOA
part of U1 snRNP IPI
IPI: Inferred from physical interaction
33677607 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
33677607 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPC Protein Structure

zf-U1

zf-U1: U1 zinc finger (1 - 38)

  • 0
  • 100
  • 159 a.a.
Protein Preferred Names Protein Names

U1 small nuclear ribonucleoprotein C

  • U1 small nuclear RNP specific C

SNRPC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SNRPC P09234 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
Intra
SNRPC P09234 BCAS2 Homo sapiens O75934
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 BCAS2 Homo sapiens O75934
Y2H Array
32296183
Intra
SNRPC P09234 BCAS2 Homo sapiens O75934
Anti Tag CoIP
35271311
Intra
SNRPC P09234 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
SNRPC P09234 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
Intra
SNRPC P09234 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
Intra
SNRPC P09234 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
SNRPC P09234 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
Intra
SNRPC P09234 SPAG8 Homo sapiens Q99932-2
Validated Y2H
32296183
Intra
SNRPC P09234 SPAG8 Homo sapiens Q99932-2
Y2H Array
32296183
Intra
SNRPC P09234 SPAG8 Homo sapiens Q99932-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
SNRPC P09234 ACTMAP Homo sapiens Q5BKX5-3
Validated Y2H
32296183
Intra
SNRPC P09234 ACTMAP Homo sapiens Q5BKX5-3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 ACTMAP Homo sapiens Q5BKX5-3
Y2H Array
32296183
Intra
SNRPC P09234 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 BOLL Homo sapiens Q8N9W6-4
Validated Y2H
32296183
Intra
SNRPC P09234 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra
SNRPC P09234 RUNX1 Homo sapiens Q01196-8
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 RUNX1 Homo sapiens Q01196-8
Validated Y2H
32296183
Intra
SNRPC P09234 RUNX1 Homo sapiens Q01196-8
Y2H Array
32296183
Intra
SNRPC P09234 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
Intra
SNRPC P09234 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
SNRPC P09234 UFSP1 Homo sapiens Q6NVU6
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 UFSP1 Homo sapiens Q6NVU6
Validated Y2H
32296183
Intra
SNRPC P09234 UFSP1 Homo sapiens Q6NVU6
Y2H Array
32296183
Intra
SNRPC P09234 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
SNRPC P09234 ANKRD10 Homo sapiens Q9NXR5-2
Y2H Array
32296183
Intra
SNRPC P09234 FUBP1 Homo sapiens Q96AE4-2
Validated Y2H
32296183
Intra
SNRPC P09234 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
Intra
SNRPC P09234 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 FAM168B Homo sapiens A1KXE4-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 FAM168B Homo sapiens A1KXE4-2
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP19-2 Homo sapiens Q3LHN2
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
Intra
SNRPC P09234 PRR20D Homo sapiens P86480
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 PRR20D Homo sapiens P86480
Validated Y2H
32296183
Intra
SNRPC P09234 PRR20D Homo sapiens P86480
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP19-6 Homo sapiens Q3LI70
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
SNRPC P09234 EYA2 Homo sapiens O00167-2
Y2H Array
32296183
Intra
SNRPC P09234 EYA2 Homo sapiens O00167-2
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 STH Homo sapiens Q8IWL8
Y2H Array
32296183
Intra
SNRPC P09234 STH Homo sapiens Q8IWL8
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 STH Homo sapiens Q8IWL8
Validated Y2H
32296183
Intra
SNRPC P09234 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
SNRPC P09234 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra
SNRPC P09234 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 TIA1 Homo sapiens P31483
Anti Bait CoIP
12486009
Intra
SNRPC P09234 TIA1 Homo sapiens P31483
Pull Down
12486009
Intra
SNRPC P09234 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP7-1 Homo sapiens Q8IUC3
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP7-1 Homo sapiens Q8IUC3
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KRTAP21-2 Homo sapiens Q3LI59
Validated Y2H
32296183
Intra
SNRPC P09234 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
SNRPC P09234 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 MKRN3 Homo sapiens Q13064
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 MKRN3 Homo sapiens Q13064
Y2H Array
32296183
Intra
SNRPC P09234 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
SNRPC P09234 SF3A2 Homo sapiens Q15428
Anti Tag CoIP
35271311
Intra
SNRPC P09234 SF3A2 Homo sapiens Q15428
Affinity Chrom
17332742
Intra
SNRPC P09234 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
SNRPC P09234 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 HNRNPDL Homo sapiens O14979
Anti Tag CoIP
35271311
Intra
SNRPC P09234 HNRNPDL Homo sapiens O14979
Y2H Array
32296183
Intra
SNRPC P09234 HNRNPH1 Homo sapiens P31943
Validated Y2H
32296183
Intra
SNRPC P09234 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
SNRPC P09234 AKAP8L Homo sapiens Q9ULX6
Anti Tag CoIP
35271311
Intra
SNRPC P09234 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
SNRPC P09234 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
SNRPC P09234 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
SNRPC P09234 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
SNRPC P09234 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
SNRPC P09234 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Intra
SNRPC P09234 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
SNRPC P09234 TRIB3 Homo sapiens Q96RU7
Y2H Array
32296183
Intra
SNRPC P09234 TRIB3 Homo sapiens Q96RU7
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 TRIB3 Homo sapiens Q96RU7
Validated Y2H
32296183
Intra
SNRPC P09234 ODAM Homo sapiens A1E959
Y2H Array
32296183
Intra
SNRPC P09234 ODAM Homo sapiens A1E959
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
SNRPC P09234 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
SNRPC P09234 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 RBM10 Homo sapiens P98175
Anti Tag CoIP
22365833
Intra
SNRPC P09234 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra
SNRPC P09234 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
SNRPC P09234 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 PLA2G10 Homo sapiens O15496
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 PLA2G10 Homo sapiens O15496
Y2H Array
32296183
Intra
SNRPC P09234 RBPMS Homo sapiens Q93062-3
Validated Y2H
32296183
Intra
SNRPC P09234 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra
SNRPC P09234 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 HOXA1 Homo sapiens P49639
Validated Y2H
32296183
Intra
SNRPC P09234 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
SNRPC P09234 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
SNRPC P09234 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
SNRPC P09234 HSD17B14 Homo sapiens Q9BPX1
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
Intra
SNRPC P09234 HSD17B14 Homo sapiens Q9BPX1
Y2H Array
32296183
Intra
SNRPC P09234 SEC23B Homo sapiens Q15437
Validated Y2H
32296183
Intra
SNRPC P09234 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 SEC23B Homo sapiens Q15437
Y2H Array
32296183
Intra
SNRPC P09234 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra
SNRPC P09234 RAMAC Homo sapiens Q9BTL3
Y2H Array
32296183
Intra
SNRPC P09234 RAMAC Homo sapiens Q9BTL3
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 RAMAC Homo sapiens Q9BTL3
Validated Y2H
32296183
Intra
SNRPC P09234 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 INTS11 Homo sapiens Q5TA45
Validated Y2H
32296183
Intra
SNRPC P09234 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
SNRPC P09234 ARHGAP9 Homo sapiens Q9BRR9
Validated Y2H
32296183
Intra
SNRPC P09234 ARHGAP9 Homo sapiens Q9BRR9
Y2H Array
32296183
Intra
SNRPC P09234 ARHGAP9 Homo sapiens Q9BRR9
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KLF1 Homo sapiens Q13351
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 KLF1 Homo sapiens Q13351
Validated Y2H
32296183
Intra
SNRPC P09234 KLF1 Homo sapiens Q13351
Y2H Array
32296183
Intra
SNRPC P09234 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
Intra
SNRPC P09234 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
Intra
SNRPC P09234 JMJD7 Homo sapiens P0C870
Validated Y2H
32296183
Intra
SNRPC P09234 JMJD7 Homo sapiens P0C870
Y2H Array
32296183
Intra
SNRPC P09234 JMJD7 Homo sapiens P0C870
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
SNRPC P09234 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 ECM1 Homo sapiens Q16610
Validated Y2H
32296183
Intra
SNRPC P09234 ECM1 Homo sapiens Q16610
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 ECM1 Homo sapiens Q16610
Y2H Array
32296183
Intra
SNRPC P09234 RERE Homo sapiens Q9P2R6
Y2H Prey Pooling
32296183
Intra
SNRPC P09234 RERE Homo sapiens Q9P2R6
Validated Y2H
32296183
Intra
SNRPC P09234 RERE Homo sapiens Q9P2R6
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SNRPC Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82581 U1C Antibody (YA2326) WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat
HY-P82581A U1C Antibody (YA2326)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06265 HNRNPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13504 SNRPC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SNRPC VGNC VGNC:35078
Mus musculus SNRPC MGD MGI:109489
Rattus norvegicus SNRPC RGD RGD:1306065
Others SNRPC NCBI